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XB-ART-21237
Neurosci Lett 1994 May 23;1731-2:21-6. doi: 10.1016/0304-3940(94)90141-4.
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Study on the induction of spontaneous transmitter release at early nerve-muscle contacts in Xenopus cultures.

Tabti N , Poo MM .


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During synaptogenesis, spontaneous acetylcholine release is rapidly induced by the contact of the growing neurite with the myocyte. Using Xenopus nerve-muscle co-cultures, we investigated the role of Ca2+ in the presynaptic mechanisms mediating this induction process. We found that Ca2+ influx is not necessary to induce spontaneous release and that an increase in cytosolic Ca2+ is not sufficient to trigger this release in the absence of the target cell.

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