Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Proc Natl Acad Sci U S A 1996 Nov 12;9323:13362-6. doi: 10.1073/pnas.93.23.13362.
Show Gene links Show Anatomy links

Heteromultimeric CLC chloride channels with novel properties.

Lorenz C , Pusch M , Jentsch TJ .

The skeletal muscle chloride channel CLC-1 and the ubiquitous volume-activated chloride channel CLC-2 belong to a large gene family whose members often show overlapping expression patterns. CLC-1 and CLC-2 are coexpressed in skeletal and smooth muscle and in the heart. By coexpressing CLC-1 and CLC-2 in Xenopus oocytes, we now show the formation of novel CLC-1/CLC-2 heterooligomers that yield time-independent linear chloride currents with a chloride-->bromide-->iodide selectivity sequence. Formation of heterooligomeric CLC channels increases the number and possible functions of chloride channels.

PubMed ID: 8917596
PMC ID: PMC24098
Article link: Proc Natl Acad Sci U S A

References [+] :
Ackerman, Cardiac chloride channels. 1993, Pubmed