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Vertebrate GLD2 poly(A) polymerases in the germline and the brain.
Rouhana L
,
Wang L
,
Buter N
,
Kwak JE
,
Schiltz CA
,
Gonzalez T
,
Kelley AE
,
Landry CF
,
Wickens M
.
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Cytoplasmic polyadenylation is important in the control of mRNA stability and translation, and for early animal development and synaptic plasticity. Here, we focus on vertebrate poly(A) polymerases that are members of the recently described GLD2 family. We identify and characterize two closely related GLD2 proteins in Xenopus oocytes, and show that they possess PAP activity in vivo and in vitro and that they bind known polyadenylation factors and mRNAs known to receive poly(A) during development. We propose that at least two distinct polyadenylation complexes exist in Xenopus oocytes, one of which contains GLD2; the other, maskin and Pumilio. GLD2 protein interacts with the polyadenylation factor, CPEB, in a conserved manner. mRNAs that encode GLD2 in mammals are expressed in many tissues. In the brain, mouse, and human GLD2 mRNAs are abundant in anatomical regions necessary for long-term cognitive and emotional learning. In the hippocampus, mouse GLD2 mRNA colocalizes with CPEB1 and Pumilio1 mRNAs, both of which are likely involved in synaptic plasticity. We suggest that mammalian GLD2 poly(A) polymerases are important in synaptic translation, and in polyadenylation throughout the soma.
Alarcon,
Selective modulation of some forms of schaffer collateral-CA1 synaptic plasticity in mice with a disruption of the CPEB-1 gene.
2004, Pubmed,
Xenbase
Alarcon,
Selective modulation of some forms of schaffer collateral-CA1 synaptic plasticity in mice with a disruption of the CPEB-1 gene.
2004,
Pubmed
,
Xenbase
Aravind,
Phosphoesterase domains associated with DNA polymerases of diverse origins.
1998,
Pubmed
Ballantyne,
Poly (A) polymerases in the nucleus and cytoplasm of frog oocytes: dynamic changes during oocyte maturation and early development.
1995,
Pubmed
,
Xenbase
Ballantyne,
A dependent pathway of cytoplasmic polyadenylation reactions linked to cell cycle control by c-mos and CDK1 activation.
1997,
Pubmed
,
Xenbase
Barnard,
Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation.
2004,
Pubmed
,
Xenbase
Bernstein,
Binding specificity and mRNA targets of a C. elegans PUF protein, FBF-1.
2005,
Pubmed
Bilger,
Nuclear polyadenylation factors recognize cytoplasmic polyadenylation elements.
1994,
Pubmed
,
Xenbase
Dehlin,
Repression of beta interferon gene expression in virus-infected cells is correlated with a poly(A) tail elongation.
1996,
Pubmed
Dickson,
The cleavage and polyadenylation specificity factor in Xenopus laevis oocytes is a cytoplasmic factor involved in regulated polyadenylation.
1999,
Pubmed
,
Xenbase
Dickson,
Poly(A) polymerase and the regulation of cytoplasmic polyadenylation.
2001,
Pubmed
,
Xenbase
Dubnau,
The staufen/pumilio pathway is involved in Drosophila long-term memory.
2003,
Pubmed
Ebersole,
The quaking gene product necessary in embryogenesis and myelination combines features of RNA binding and signal transduction proteins.
1996,
Pubmed
Eichenbaum,
Hippocampus: cognitive processes and neural representations that underlie declarative memory.
2004,
Pubmed
Fox,
Poly(A) addition during maturation of frog oocytes: distinct nuclear and cytoplasmic activities and regulation by the sequence UUUUUAU.
1989,
Pubmed
,
Xenbase
Frey,
Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro.
1988,
Pubmed
Fukazawa,
Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo.
2003,
Pubmed
Gebauer,
Cloning and characterization of a Xenopus poly(A) polymerase.
1995,
Pubmed
,
Xenbase
Good,
Xenopus embryonic poly(A) binding protein 2 (ePABP2) defines a new family of cytoplasmic poly(A) binding proteins expressed during the early stages of vertebrate development.
2004,
Pubmed
,
Xenbase
Hake,
Specificity of RNA binding by CPEB: requirement for RNA recognition motifs and a novel zinc finger.
1998,
Pubmed
,
Xenbase
Hentze,
Translational regulation: versatile mechanisms for metabolic and developmental control.
1995,
Pubmed
Huang,
N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA polyadenylation at synapses.
2002,
Pubmed
,
Xenbase
Huh,
Global analysis of protein localization in budding yeast.
2003,
Pubmed
Jenny,
Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit.
1994,
Pubmed
Jones,
A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories.
2001,
Pubmed
Kadaba,
Nuclear surveillance and degradation of hypomodified initiator tRNAMet in S. cerevisiae.
2004,
Pubmed
Kobayashi,
On the synthesis and destruction of A- and B-type cyclins during oogenesis and meiotic maturation in Xenopus laevis.
1991,
Pubmed
,
Xenbase
Kraemer,
NANOS-3 and FBF proteins physically interact to control the sperm-oocyte switch in Caenorhabditis elegans.
1999,
Pubmed
Kuersten,
The power of the 3' UTR: translational control and development.
2003,
Pubmed
Kwak,
Mammalian GLD-2 homologs are poly(A) polymerases.
2004,
Pubmed
,
Xenbase
Liu,
The cytoplasmic polyadenylation element binding protein and polyadenylation of messenger RNA in Aplysia neurons.
2003,
Pubmed
Lund,
Nonaqueous isolation of transcriptionally active nuclei from Xenopus oocytes.
1990,
Pubmed
,
Xenbase
Malkani,
An egr-1 (zif268) antisense oligodeoxynucleotide infused into the amygdala disrupts fear conditioning.
2004,
Pubmed
Martin,
Crystal structure of mammalian poly(A) polymerase in complex with an analog of ATP.
2000,
Pubmed
Martin,
Biochemical and structural insights into substrate binding and catalytic mechanism of mammalian poly(A) polymerase.
2004,
Pubmed
Matsuzaki,
Structural basis of long-term potentiation in single dendritic spines.
2004,
Pubmed
Mendez,
Translational control by CPEB: a means to the end.
2001,
Pubmed
,
Xenbase
Mendez,
Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complex.
2000,
Pubmed
,
Xenbase
Miller,
Disruption of dendritic translation of CaMKIIalpha impairs stabilization of synaptic plasticity and memory consolidation.
2002,
Pubmed
Muckenthaler,
Regulated poly(A) tail shortening in somatic cells mediated by cap-proximal translational repressor proteins and ribosome association.
1997,
Pubmed
Nakahata,
Biochemical identification of Xenopus Pumilio as a sequence-specific cyclin B1 mRNA-binding protein that physically interacts with a Nanos homolog, Xcat-2, and a cytoplasmic polyadenylation element-binding protein.
2001,
Pubmed
,
Xenbase
Nakahata,
Involvement of Xenopus Pumilio in the translational regulation that is specific to cyclin B1 mRNA during oocyte maturation.
2003,
Pubmed
,
Xenbase
Nguyen,
Requirement of a critical period of transcription for induction of a late phase of LTP.
1994,
Pubmed
Otmakhov,
Persistent accumulation of calcium/calmodulin-dependent protein kinase II in dendritic spines after induction of NMDA receptor-dependent chemical long-term potentiation.
2004,
Pubmed
Pang,
Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity.
2004,
Pubmed
Pawlak,
Rapid, specific and active site-catalyzed effect of tissue-plasminogen activator on hippocampus-dependent learning in mice.
2002,
Pubmed
Read,
Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest.
2002,
Pubmed
Richter,
Think globally, translate locally: what mitotic spindles and neuronal synapses have in common.
2001,
Pubmed
,
Xenbase
Romanowski,
XMCM7, a novel member of the Xenopus MCM family, interacts with XMCM3 and colocalizes with it throughout replication.
1996,
Pubmed
,
Xenbase
SCOVILLE,
Loss of recent memory after bilateral hippocampal lesions.
1957,
Pubmed
Saitoh,
Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.
2002,
Pubmed
Sheets,
The 3'-untranslated regions of c-mos and cyclin mRNAs stimulate translation by regulating cytoplasmic polyadenylation.
1994,
Pubmed
,
Xenbase
Shin,
Rapid, activity-induced increase in tissue plasminogen activator is mediated by metabotropic glutamate receptor-dependent mRNA translation.
2004,
Pubmed
Si,
A neuronal isoform of the aplysia CPEB has prion-like properties.
2003,
Pubmed
,
Xenbase
Si,
A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia.
2003,
Pubmed
,
Xenbase
Simon,
Posttranscriptional regulation of the immediate-early gene EGR1 by light in the mouse retina.
2004,
Pubmed
Sonenberg,
mRNA translation: influence of the 5' and 3' untranslated regions.
1994,
Pubmed
Sonoda,
Recruitment of Nanos to hunchback mRNA by Pumilio.
1999,
Pubmed
Stebbins-Boaz,
Maskin is a CPEB-associated factor that transiently interacts with elF-4E.
1999,
Pubmed
,
Xenbase
Steward,
Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation.
2001,
Pubmed
Tang,
Protein synthesis in the dendrite.
2002,
Pubmed
Theis,
Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus.
2003,
Pubmed
,
Xenbase
Wang,
A regulatory cytoplasmic poly(A) polymerase in Caenorhabditis elegans.
2002,
Pubmed
Wells,
Molecular mechanisms for activity-regulated protein synthesis in the synapto-dendritic compartment.
2000,
Pubmed
Wickens,
A PUF family portrait: 3'UTR regulation as a way of life.
2002,
Pubmed
Wu,
CPEB-mediated cytoplasmic polyadenylation and the regulation of experience-dependent translation of alpha-CaMKII mRNA at synapses.
1998,
Pubmed
,
Xenbase
Ye,
Nanos and Pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons.
2004,
Pubmed
