Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-26432
EMBO J 1989 Nov 01;811:3235-44. doi: 10.1002/j.1460-2075.1989.tb08483.x.
Show Gene links Show Anatomy links

Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.

Stühmer W , Ruppersberg JP , Schröter KH , Sakmann B , Stocker M , Giese KP , Perschke A , Baumann A , Pongs O .


???displayArticle.abstract???
Cloning and sequencing of cDNAs isolated from a rat cortex cDNA library reveals that a gene family encodes several highly homologous K+ channel forming (RCK) proteins. Functional characterization of the channels expressed in Xenopus laevis oocytes following microinjection of in vitro transcribed RCK-specific RNAs shows that each of the RCK proteins forms K+ channels that differ greatly in both their functional and pharmacological properties. This suggests that the molecular basis for the diversity of voltage-gated K+ channels in mammalian brain is based, at least partly, on the expression of several RCK proteins by a family of genes and their assembly to homooligomeric K+ channels with different functional properties.

???displayArticle.pubmedLink??? 2555158
???displayArticle.pmcLink??? PMC401447
???displayArticle.link??? EMBO J
???displayArticle.grants??? [+]

Species referenced: Xenopus laevis

References [+] :
Baumann, Structure of the voltage-dependent potassium channel is highly conserved from Drosophila to vertebrate central nervous systems. 1988, Pubmed