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Eur Biophys J
2004 May 01;333:211-26. doi: 10.1007/s00249-003-0373-0.
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Some aspects of the physiological role of ion channels in the nervous system.
Pichon Y
,
Prime L
,
Benquet P
,
Tiaho F
.
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Recent analyses of the genomes of several animal species, including man, have revealed that a large number of ion channels are present in the nervous system. Our understanding of the physiological role of these channels in the nervous system has followed the evolution of biophysical techniques during the last century. The observation and the quantification of the electrical events associated with the operation of the ionic channels has been, and still is, one of the best tools to analyse the various aspects of their contribution to nerve function. For this reason, we have chosen to use electrophysiological recordings to illustrate some of the main functions of these channels. The properties and the roles of Na+ and K+ channels in neuronal resting and action potentials are illustrated in the case of the giant axons of the squid and the cockroach. The nature and role of the calcium currents in the bursting behaviour of the neurons are illustrated for Aplysia giant neurons. The relationship between presynaptic calcium currents and synaptic transmission is shown for the squid giant synapse. The involvement of calcium channels in survival and neurite outgrowth of cultured neurons is exemplified using embryonic cockroach brain neurons. This same neuronal preparation is used to illustrate ion channel noise and single-channel events associated with the binding of agonists to nicotinic receptors. Some features of the synaptic activity in the central nervous system are shown, with examples from the cercal nerve giant-axon preparation of the cockroach. The interplay of different ion conductances involved in the oscillatory behaviour of the Xenopus spinal motoneurons is illustrated and discussed. The last part of this review deals with ionic homeostasis in the brain and the function of glial cells, with examples from Necturus and squids.
Alessandri-Haber,
Molecular determinants of emerging excitability in rat embryonic motoneurons.
2002, Pubmed
Alessandri-Haber,
Molecular determinants of emerging excitability in rat embryonic motoneurons.
2002,
Pubmed
Anderson,
Voltage clamp analysis of acetylcholine produced end-plate current fluctuations at frog neuromuscular junction.
1973,
Pubmed
Augustine,
Calcium entry and transmitter release at voltage-clamped nerve terminals of squid.
1985,
Pubmed
BOISTEL,
[Role played by sodium ions in the genesis of electric activity of nerve tissue in insects].
1958,
Pubmed
BROCK,
The recording of potentials from motoneurones with an intracellular electrode.
1952,
Pubmed
Baranauskas,
Delayed rectifier currents in rat globus pallidus neurons are attributable to Kv2.1 and Kv3.1/3.2 K(+) channels.
1999,
Pubmed
Benquet,
Differential involvement of Ca(2+) channels in survival and neurite outgrowth of cultured embryonic cockroach brain neurons.
2002,
Pubmed
Benquet,
omega-AgaIVA-sensitive (P/Q-type) and -resistant (R-type) high-voltage-activated Ba(2+) currents in embryonic cockroach brain neurons.
1999,
Pubmed
Callec,
Further studies on synaptic transmission in insects. II. Relations between sensory information and its synaptic integration at the level of a single giant axon in the cockroach.
1971,
Pubmed
Christensen,
Ionic currents in neurones cultured from embryonic cockroach (Periplaneta americana) brains.
1988,
Pubmed
DALTON,
Effects of external ions on membrane potentials of a crayfish giant axon.
1959,
Pubmed
DALTON,
Effects of external ions on membrane potentials of a lobster giant axon.
1958,
Pubmed
Dale,
Kinetic characterization of the voltage-gated currents possessed by Xenopus embryo spinal neurons.
1995,
Pubmed
,
Xenbase
Debarbieux,
Action potential propagation in dendrites of rat mitral cells in vivo.
2003,
Pubmed
FRANKENHAEUSER,
The after-effects of impulses in the giant nerve fibres of Loligo.
1956,
Pubmed
Gorman,
Changes in the intracellular concentration of free calcium ions in a pace-maker neurone, measured with the metallochromic indicator dye arsenazo III.
1978,
Pubmed
Gu,
Low-threshold Ca2+ current and its role in spontaneous elevations of intracellular Ca2+ in developing Xenopus neurons.
1993,
Pubmed
,
Xenbase
HODGKIN,
A quantitative description of membrane current and its application to conduction and excitation in nerve.
1952,
Pubmed
HODGKIN,
Measurement of current-voltage relations in the membrane of the giant axon of Loligo.
1952,
Pubmed
Hamill,
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.
1981,
Pubmed
Hansen,
The extracellular potassium concentration in brain cortex following ischemia in hypo- and hyperglycemic rats.
1978,
Pubmed
Hines,
NEURON: a tool for neuroscientists.
2001,
Pubmed
Katz,
The statistical nature of the acetycholine potential and its molecular components.
1972,
Pubmed
Kazarinova-Noyes,
Molecular constituents of the node of Ranvier.
2002,
Pubmed
Klumpp,
The Shaker-like potassium channels of the mouse rod bipolar cell and their contributions to the membrane current.
1995,
Pubmed
Lambolez,
AMPA receptor subunits expressed by single Purkinje cells.
1992,
Pubmed
MARMONT,
Studies on the axon membrane; a new method.
1949,
Pubmed
Mathie,
What are the roles of the many different types of potassium channel expressed in cerebellar granule cells?
2003,
Pubmed
Mochida,
Subtype-selective reconstitution of synaptic transmission in sympathetic ganglion neurons by expression of exogenous calcium channels.
2003,
Pubmed
Neher,
Single-channel currents recorded from membrane of denervated frog muscle fibres.
1976,
Pubmed
Nowak,
Magnesium gates glutamate-activated channels in mouse central neurones.
,
Pubmed
Orkand,
Effect of nerve impulses on the membrane potential of glial cells in the central nervous system of amphibia.
1966,
Pubmed
Pal,
Mediation of neuronal apoptosis by Kv2.1-encoded potassium channels.
2003,
Pubmed
Pichon,
Pharmacological characterization of ionic channels in unmyelinated axons.
1981,
Pubmed
Pichon,
Further studies on synaptic transmission in insects. I. External recording of synaptic potentials in a single giant axon of the cockroach, Periplaneta americana L.
1970,
Pubmed
Prime,
Role of ligand-gated ion channels in the swimming behaviour of Xenopus tadpoles: experimental data and modelling experiments.
2004,
Pubmed
,
Xenbase
Prime,
N-Methyl-D-aspartate-induced oscillations in whole cell clamped neurons from the isolated spinal cord of Xenopus laevis embryos.
1999,
Pubmed
,
Xenbase
Rasband,
Developmental clustering of ion channels at and near the node of Ranvier.
2001,
Pubmed
Salzer,
Nodes of Ranvier come of age.
2002,
Pubmed
Sutherland,
Overexpression of a Shaker-type potassium channel in mammalian central nervous system dysregulates native potassium channel gene expression.
1999,
Pubmed
TAUC,
Cholinergic transmission mechanisms for both excitation and inhibition in molluscan central synapses.
1961,
Pubmed
Vabnick,
Ion channel redistribution and function during development of the myelinated axon.
1998,
Pubmed
Wallén,
N-methyl-D-aspartate receptor-induced, inherent oscillatory activity in neurons active during fictive locomotion in the lamprey.
1987,
Pubmed