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A part of the eyeprimordium, the presumptive retinal anlage, was transplanted from stage-23/24 Xenopus borealis to replace the removed olfactory anlage of Xenopus laevis. Cells of the two species can be distinguished under fluorescence microscopy, and we used the resulting chimeras to determine whether the transplanted eyeprimordium would inhibit the regeneration of the olfactory anlage, whether it would connect with its usual target, the diencephalon, and whether migration of cells would occur from the transplant to the host CNS or from the host CNS to the transplant. In all cases, the olfactory anlage regenerated promptly, and normal olfactory bulbs developed. Omission of the eye stalk in the transplant resulted in failure of an optic nerve to develop from the developing retina. A cellular bridge containing the optic axons connected the transplanted retina to the diencephalon. Cells from the transplant migrated freely through the cellular bridge to several CNS regions. Their morphology, topographic arrangement, number, and relations with other host elements are consistent with the hypothesis that these cells belong to both glia and neuron types.
Adler,
Plasticity and differentiation of embryonic retinal cells after terminal mitosis.
1989, Pubmed
Adler,
Plasticity and differentiation of embryonic retinal cells after terminal mitosis.
1989,
Pubmed
Altshuler,
A temporally regulated, diffusible activity is required for rod photoreceptor development in vitro.
1992,
Pubmed
Cepko,
Lineage versus environment in the embryonic retina.
1993,
Pubmed
Constantine-Paton,
Central projection of optic tract from translocated eyes in the leopard frog (Rana pipiens).
1975,
Pubmed
Constantine-Paton,
Eye-specific termination bands in tecta of three-eyed frogs.
1978,
Pubmed
Constantine-Paton,
Axonal guidance of developing optic nerves in the frog. II. electrophysiological studies of the projection from transplanted eye primordia.
1976,
Pubmed
Constantine-Paton,
Axonal guidance of developing optic nerves in the frog. I. Anatomy of the projection from transplanted eye primordia.
1976,
Pubmed
Fujisawa,
Branching of regenerating retinal axons and preferential selection of appropriate branches for specific neuronal connection in the newt.
1982,
Pubmed
Fujisawa,
Retinotopic analysis of fiber pathways is amphibians. I. The adult newt Cynops pyrrhogaster.
1981,
Pubmed
Galileo,
Neurons and glia arise from a common progenitor in chicken optic tectum: demonstration with two retroviruses and cell type-specific antibodies.
1990,
Pubmed
Gimlich,
Cell lineage and the induction of second nervous systems in amphibian development.
,
Pubmed
,
Xenbase
Graziadei,
The influence of the olfactory placode on the development of the telencephalon in Xenopus laevis.
1992,
Pubmed
,
Xenbase
Graziadei,
Neuronal changes in the forebrain of mice following penetration by regenerating olfactory axons.
1986,
Pubmed
,
Xenbase
Graziadei,
Principles of organization of the vertebrate olfactory glomerulus: an hypothesis.
1986,
Pubmed
,
Xenbase
Graziadei,
Ectopic glomerular structures in the olfactory bulb of neonatal and adult mice.
1980,
Pubmed
Harris,
Homing behaviour of axons in the embryonic vertebrate brain.
,
Pubmed
,
Xenbase
Harris,
Lineage versus environment in the embryonic retina.
1993,
Pubmed
Harris,
Local positional cues in the neuroepithelium guide retinal axons in embryonic Xenopus brain.
1989,
Pubmed
,
Xenbase
Holt,
Cell movements in Xenopus eye development.
1980,
Pubmed
,
Xenbase
Hunt,
Cell patterning in pigment-chimeric eyes in Xenopus: germinal transplants and their contributions to growth of the pigmented retinal epithelium.
1987,
Pubmed
,
Xenbase
Hunt,
Cell patterning in pigment-chimeric eyes of Xenopus: local cues control the decision to become germinal cells.
1987,
Pubmed
,
Xenbase
Koo,
Cell migration from the transplanted olfactory placode in Xenopus.
1995,
Pubmed
,
Xenbase
Magrassi,
Interaction of the transplanted olfactory placode with the optic stalk and the diencephalon in Xenopus laevis embryos.
1985,
Pubmed
,
Xenbase
Reh,
Cell-specific regulation of neuronal production in the larval frog retina.
1987,
Pubmed
Reh,
Cellular interactions determine neuronal phenotypes in rodent retinal cultures.
1992,
Pubmed
Sheard,
Clonal restriction boundaries in Xenopus embryos shown with two intracellular lineage tracers.
1987,
Pubmed
,
Xenbase
Small,
Evidence for migration of oligodendrocyte--type-2 astrocyte progenitor cells into the developing rat optic nerve.
,
Pubmed
Stout,
Influence of the olfactory placode on the development of the brain in Xenopus laevis (Daudin). I. Axonal growth and connections of the transplanted olfactory placode.
1980,
Pubmed
,
Xenbase
Thiébaud,
A reliable new cell marker in Xenopus.
1983,
Pubmed
,
Xenbase
Turner,
A common progenitor for neurons and glia persists in rat retina late in development.
,
Pubmed
Watanabe,
Retinal astrocytes are immigrants from the optic nerve.
1988,
Pubmed
Watanabe,
Diffusible rod-promoting signals in the developing rat retina.
1992,
Pubmed
Wetts,
Multipotent precursors can give rise to all major cell types of the frog retina.
1988,
Pubmed
,
Xenbase
Williams,
Structure of clonal and polyclonal cell arrays in chimeric mouse retina.
1992,
Pubmed
Williams,
Lineage versus environment in embryonic retina: a revisionist perspective.
1992,
Pubmed
