XB-ART-12993
Science
1999 May 21;2845418:1356-8.
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Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran.
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The nucleotide exchange activity of RCC1, the only known nucleotide exchange factor for Ran, a Ras-like small guanosine triphosphatase, was required for microtubule aster formation with or without demembranated sperm in Xenopus egg extracts arrested in meiosis II. Consistently, in the RCC1-depleted egg extracts, Ran guanosine triphosphate (RanGTP), but not Ran guanosine diphosphate (RanGDP), induced self-organization of microtubule asters, and the process required the activity of dynein. Thus, Ran was shown to regulate formation of the microtubule network.
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Species referenced: Xenopus
Genes referenced: ran rcc1
References :