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Dev Biol 2000 Nov 01;2271:118-32. doi: 10.1006/dbio.2000.9873.
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Different activities of the frizzled-related proteins frzb2 and sizzled2 during Xenopus anteroposterior patterning.

Bradley L , Sun B , Collins-Racie L , LaVallie E , McCoy J , Sive H .

In a search for factors that regulate patterning of the Xenopus anteroposterior (A/P) axis, particularly the anterior ectoderm, we isolated two members of the Frizzled-related protein (FRP) gene family that are thought to encode antagonists of Wnt signaling. frzb2 is expressed in head mesoderm while sizzled2 is expressed in ventral ectoderm and mesoderm, tissues that modulate anterior fates. Consistent with a role for these genes in A/P patterning, ectopically expressed frzb2 inhibited head formation, while sizzled2 dorsalized embryos, causing expansion of the head. The different activities of frzb2 and sizzled2 may be explained by their interaction with distinct proteins since frzb2 is an inhibitor of Xwnt8 activity, while sizzled2 is unable to inhibit the activity of Xwnt8 or any other Xwnt tested. The data suggest that anteroposterior patterning is modulated by multiple components of the Wnt signaling pathway.

PubMed ID: 11076681
Article link: Dev Biol

Species referenced: Xenopus laevis
Genes referenced: acta4 actc1 actl6a chrd egr2 frzb frzb2 gata2 gsc hoxb9 inhba muc2 nkx2-5 odc1 otx2 sfrp1 shh sia1 szl tbx2 tfap2a wnt3a wnt8a

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