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Curr Opin Genet Dev 2007 Aug 01;174:326-31. doi: 10.1016/j.gde.2007.05.012.
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Modulating the activity of neural crest regulatory factors.

Taylor KM , LaBonne C .

Substantial progress has been made in defining the regulatory factors involved in generating multipotent neural crest cells at the neural plate border of vertebrate embryos, controlling the onset of their migratory behavior, and directing their differentiation into one of a diverse array of derivatives. Growing evidence suggests that these factors function as a complex network, in some cases displaying overlapping functions and cross-regulatory interactions. Mechanisms are emerging for how some of these regulatory components are controlled post-translationally and the extent to which their activities are conserved across species.

PubMed ID: 17651964
Article link: Curr Opin Genet Dev
Grant support: [+]

Species referenced: Xenopus
Genes referenced: ascl1 bmp1 fbxl14 foxd3 hand2 id3 itk mitf myc neurog2 pax3 phox2b snai1 snai2 sox10 sox9 twist1 wnt1

Article Images: [+] show captions