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Dev Biol 2008 Aug 01;3201:199-214. doi: 10.1016/j.ydbio.2008.05.523.
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Eya1 and Six1 promote neurogenesis in the cranial placodes in a SoxB1-dependent fashion.

Schlosser G , Awtry T , Brugmann SA , Jensen ED , Neilson K , Ruan G , Stammler A , Voelker D , Yan B , Zhang C , Klymkowsky MW , Moody SA .

Genes of the Eya family and of the Six1/2 subfamily are expressed throughout development of vertebrate cranial placodes and are required for their differentiation into ganglia and sense organs. How they regulate placodal neurogenesis, however, remains unclear. Through loss of function studies in Xenopus we show that Eya1 and Six1 are required for neuronal differentiation in all neurogenic placodes. The effects of overexpression of Eya1 or Six1 are dose dependent. At higher levels, Eya1 and Six1 expand the expression of SoxB1 genes (Sox2, Sox3), maintain cells in a proliferative state and block expression of neuronal determination and differentiation genes. At lower levels, Eya1 and Six1 promote neuronal differentiation, acting downstream of and/or parallel to Ngnr1. Our findings suggest that Eya1 and Six1 are required for both the regulation of placodal neuronal progenitor proliferation, through their effects on SoxB1 expression, and subsequent neuronal differentiation.

PubMed ID: 18571637
PMC ID: PMC2671077
Article link: Dev Biol
Grant support: [+]

Species referenced: Xenopus
Genes referenced: cdknx dll1 eya1 myc neurod1 neurog2 pcna six1 sox2 sox3 tubb2b
Antibodies: Myc Ab3 Pcna Ab1 Sox3 Ab1
Morpholinos: eya1 MO1 eya1 MO2 six1 MO1 six1 MO2 sox2 MO4 sox3 MO3

Article Images: [+] show captions
References [+] :
Abu-Elmagd, cSox3 expression and neurogenesis in the epibranchial placodes. 2001, Pubmed