GEO Series: GSE130448
Summary
This study was conducted to investigate the effects of DN-tp63 loss-of-function on mucociliary basal stem cells in Xenopus laevis. Uninjected control embryos and DN-tp63 morpholino oligonucleotide injected embryos were used to generate animal cap explants at embryonic stage 8. Explants were grown into mucociliary organoids and collected at embryonic stages 10.5, 16-19, and 24-25 for total RNA extraction.
Contributors: Peter Walentek
Experiment Type: The experiment was conducted in three biological replicates (embryos were derived from three different females and fertilizations). Control samples remained uninjected, DN-tp63 morphant samples were injected with morpholino oligonucleotides targeting the start condon of DN-tp63 and resulted in protein knockdown (loss-of-function). Sequencing was performed in two seperate paired-end runs to increase sequencing dpth, with each run containing all samples.
Experiment Reagents: tp63 MO3.
Phenotypes:
Article: XB-ART-56304, PubMed
Source: NCBI GEO, Xenbase Download
Samples: (DEG = Differentially Expressed Genes; GSM = GEO Sample Number)
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