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Gene/Clone	Species	Stage	Anatomy Item	Experimenter
six1	xenopus		otic placode [+] amphibian papilla,anterior crista,auditory hair cell,auditory ossicle,auditory tube,basilar papilla,endolymphatic duct,footplate of the stapes,inner ear,lagena,lateral crista,middle ear,osseous labyrinth,otic capsule,oval window,pars externa of the stapes,pars interna of the stapes,pars media of the stapes,posterior crista,prootic bone,saccular macula,semicircular canal,stapes,tympanic annulus,tympanic disk,vestibular apparatus,vestibule,auditory apparatus,otic capsule,otic vesicle,vestibulocochlear ganglion

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Expression summary for six1

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Experiment	Species	Images	Stages	Anatomy	Assay
Schlosser G and Ahrens K (2004) Assay Paper	laevis	3 images	NF stage 21 to NF stage 33 and 34	otic placode	in situ hybridization
Schlosser G et al. (2008) Assay Paper	laevis	1 image	NF stage 26	otic vesicle	in situ hybridization
Harland Lab Assay Harland Lab	tropicalis	2 images	NF stage 27 to NF stage 33 and 34	otic vesicle	in situ hybridization
Xenopus Eya1 demarcates all neurogenic placodes as well as migrating hypaxial muscle precursors. Paper	laevis	1 image	NF stage 29 and 30 to NF stage 33 and 34	otic vesicle	in situ hybridization
Molecular cloning and embryonic expression of Xenopus Six homeobox genes. Paper	laevis	2 images	NF stage 29 and 30	otic vesicle	in situ hybridization
Xenopus Six1 gene is expressed in neurogenic cranial placodes and maintained in the differentiating lateral lines. Paper	laevis	1 image	NF stage 32 to NF stage 39	inner ear	in situ hybridization
Hairy2-Id3 interactions play an essential role in Xenopus neural crest progenitor specification. Paper	laevis	1 image	NF stage 27	otic vesicle	in situ hybridization
RIPPLY3 is a retinoic acid-inducible repressor required for setting the borders of the pre-placodal ectoderm. Paper	laevis	1 image	NF stage 32	otic vesicle	in situ hybridization
Tissues and signals involved in the induction of placodal Six1 expression in Xenopus laevis. Paper	laevis	1 image	NF stage 20 to NF stage 26	otic placode	in situ hybridization
Yes-associated protein 65 (YAP) expands neural progenitors and regulates Pax3 expression in the neural plate border zone. Paper	laevis	1 image	NF stage 24	otic placode	in situ hybridization
The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis. Paper	laevis	1 image	NF stage 26 to NF stage 33 and 34	otic vesicle	in situ hybridization
Dissecting the pre-placodal transcriptome to reveal presumptive direct targets of Six1 and Eya1 in cranial placodes. Paper	laevis	1 image	NF stage 24 to NF stage 28	otic placode, otic vesicle	in situ hybridization
Dissecting the pre-placodal transcriptome to reveal presumptive direct targets of Six1 and Eya1 in cranial placodes. Paper	laevis	1 image	NF stage 24 to NF stage 28	otic vesicle	in situ hybridization
Dissecting the pre-placodal transcriptome to reveal presumptive direct targets of Six1 and Eya1 in cranial placodes. Paper	laevis	1 image	NF stage 24 to NF stage 28	otic vesicle	in situ hybridization
Dissecting the pre-placodal transcriptome to reveal presumptive direct targets of Six1 and Eya1 in cranial placodes. Paper	laevis	1 image	NF stage 24 to NF stage 28	otic placode, otic vesicle	in situ hybridization
Pa2G4 is a novel Six1 co-factor that is required for neural crest and otic development. Paper	laevis	1 image	NF stage 28	otic vesicle	in situ hybridization
Pa2G4 is a novel Six1 co-factor that is required for neural crest and otic development. Paper	laevis	1 image	NF stage 28	otic vesicle	in situ hybridization
Neilson KM et al. (2016) Assay Paper	laevis	1 image	NF stage 33 and 34 to NF stage 35 and 36	otic vesicle	in situ hybridization
Adams DS et al. (2016) Assay Paper	laevis	2 images	NF stage 18 to NF stage 28	otic placode, otic vesicle	in situ hybridization
Sullivan CH et al. (2019) Assay Paper	laevis	1 image	NF stage 24 to NF stage 28	otic vesicle	in situ hybridization
Mcrs1 interacts with Six1 to influence early craniofacial and otic development. Paper	laevis	1 image	NF stage 28 to NF stage 33 and 34	otic vesicle	in situ hybridization
Tavares ALP et al. (2021) Assay Paper	laevis	3 images	NF stage 28 to NF stage 33 and 34	otic vesicle	in situ hybridization

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