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Gene/Clone	Species	Stage	Anatomy Item	Experimenter
map3k20	xenopus		optic field [+] Muller cell,amacrine cell,bipolar neuron,central retina,choroid,choroid fissure,ciliary body,ciliary marginal zone,conjunctiva,cornea,eye photoreceptor cell,globe,horizontal cell,inner limiting membrane,iris,lens,lens epithelium,lens fiber cell mass,lens placode,lens transitional zone,lower eyelid,optic disc,optic fiber layer,optic nerve,outer limiting membrane,peripheral retina,photoreceptor layer,pigment layer,pupil,retina,retinal ganglion cell,retinal ganglion cell layer,retinal inner nuclear layer,retinal inner plexiform layer,retinal layer,retinal neural layer,retinal outer nuclear layer,retinal outer plexiform layer,retinal pigmented epithelium,retinal progenitor cell,retinal progenitor cell region,retinal stem cell,retinal stem cell region,sclera,choroid fissure,eye,eye primordium,iris,optic nerve,optic stalk,optic vesicle

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Experiment details for map3k20

The protein kinase MLTK regulates chondrogenesis by inducing the transcription factor Sox6.

The protein kinase MLTK regulates chondrogenesis by inducing the transcription factor Sox6.

Gene	Clone	Species	Stages	Anatomy
map3k20.L		laevis	NF stage 37 and 38	optic field

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Fig. 1. xMLTK is required for craniofacial cartilage formation. (A) Whole-mount in situ hybridization for xMLTKα and xMLTKβ was performed on embryos at stages 17, 24, 37/38 and 41. OV, otic vesicle; G, glomus; PD, pronephric duct; No, notochord; F, left-rostral furrow in yolk mass; PM, paraxial mesoderm; FM, facial muscle; BA, branchial arch. (B) Magnified view of embryos at stage 41 shown in A. M, Meckel’s cartilage; CH, ceratohyal cartilage; CB, ceratobranchial cartilage; OV, otic vesicle; G, glomus; F, left-rostral furrow in yolk mass; MQH, m. quadrato-hyoangularis; MOH, m. orbitohyoideus; MIH, m. interhyoideus; MLM, m. levator mandibulae. (C) xMLTK-MO or 5misMO was injected into the animal pole of all blastomeres (10 ng/cell) at the four-cell stage, and the embryos were fixed at stage 45. (D) Magnified view of the head of the embryo shown in C. Craniofacial cartilage is outlined with a dashed yellow line. (E) xMLTK-MO (n=29), xMLTK-MO plus xMLTKα-res-myc plasmid (n=25), or xMLTK-MO plus xMLTKβ-res-myc plasmid (n=25) was injected unilaterally into the animal pole of two blastomeres (xMLTK-MO, 10 ng/cell; plasmid, 50 pg /cell) at the four-cell stage. Uninjected embryos (n=31) and injected embryos were fixed at stage 45, and cartilages were stained with Alcian Blue. Brackets indicate the injected side. M, Meckel’s cartilage; CH, ceratohyal cartilage; CB, ceratobranchial cartilage; BHB, basihyobranchial cartilage. (F) The relative cartilage size (the rate of the length of the right side to that of the left side of ceratohyal cartilages) was quantified. Values are mean±s.d. **P<0.01.