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dyrk1axenopus optic vesicle [+] 

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Experiment details for dyrk1a

Willsey HR et al. (2020) Assay

The neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and control of brain size in Xenopus embryos.

Gene Clone Species Stages Anatomy
dyrk1a image:7687837 tropicalis NF stage 20 optic vesicle
dyrk1a image:7687837 tropicalis NF stage 32 optic vesicle
dyrk1a image:7687837 tropicalis NF stage 35 and 36 eye
dyrk1a image:7687837 tropicalis NF stage 40 eye

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  Fig. 1. Expression and localization of Dyrk1a during X. tropicalis development. (A-F) RNA in situ hybridization in X. tropicalis. (A-B′) dyrk1a is expressed during gastrulation (stage 10.5, A) and at stage 20 (B) in the brain, spinal cord, optic vesicles and ciliated epidermis (B′). (C,D) At stages 32 (C) and 35 (D), dyrk1a is expressed in the brain, spinal cord, otic vesicles, optic vesicles, pharyngeal arches, heart, epidermis and pronephros. (E,F) At stages 40 (E) and 46 (F), dyrk1a is expressed in the brain, especially along ventricles [telencephalon (tel), diencephalon (di), mesencephalon (mes) and rhombencephalon (rhomb)]. Scale bars: 500 µm; 100 µm in B′. (G-G‴) Embryonic epidermis antibody staining for Dyrk1a protein (green) shows puncta along ciliary axonemes labeled for acetylated α-Tubulin (Ac-α-Tubulin, magenta). See Fig. S1 for antibody validation. (H) Dorsal view of whole-mount antibody staining showing Dyrk1a (green) throughout the nervous system and in the pronephros (pro). (I-J′) Dyrk1a (green) is on cilia marked by polyglutamylated-Tubulin (polyglut-Tubulin, magenta) in the olfactory epithelium (olf, I,I′) and in the rhombencephalon (J-J′). White arrows (I′) indicate the puncta of Dyrk1a (green) on cilia. There is also strong membrane staining. (K-K′) Human GFP-tagged DYRK1A (hDYRK1A-GFP, green) localizes in puncta along ciliary axonemes labeled for acetylated α-Tubulin (magenta). (L-L′) hDYRK1A-GFP (green) colocalizes with Centrin-CFP (cyan) at basal bodies.

Gene Clone Species Stages Anatomy
dyrk1a image:7687837 tropicalis NF stage 20 optic vesicle

  dyrk1a (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A) gene expression in a Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage 20, lateral view, anterior left, dorsal up.

Gene Clone Species Stages Anatomy
dyrk1a image:7687837 tropicalis NF stage 35 and 36 optic vesicle

  dyrk1a (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A) gene expression in a Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage 35 & 36, lateral view, anterior left, dorsal up.

Gene Clone Species Stages Anatomy
dyrk1a image:7687837 tropicalis NF stage 40 optic vesicle , eye

  dyrk1a (dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A) gene expression in a Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage 40, dorsal view, anterior up.

Gene Clone Species Stages Anatomy
dyrk1a image:7687837 tropicalis NF stage 46 optic nerve , eye

  Whole-mount antibody Dyrk1a Ab1 [AB_1209558] staining showing Dyrk1a (green) throughout the nervous system and in the pronephros in a stage NF stage 46, Xenopus tropicalis embryo, dorsal view, anterior up. Key: olf: olfactory epithelia, tel: telencephalon, di: diencephalon, mes: mesencephalon/midbrain, rhomb: rhombencephalon/hindbrain, pro: pronephric kidney, eye: eye.