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Gene/Clone	Species	Stage	Anatomy Item	Experimenter
sox10	xenopus		optic field [+] Muller cell,amacrine cell,bipolar neuron,central retina,choroid,choroid fissure,ciliary body,ciliary marginal zone,conjunctiva,cornea,eye photoreceptor cell,globe,horizontal cell,inner limiting membrane,iris,lens,lens epithelium,lens fiber cell mass,lens placode,lens transitional zone,lower eyelid,optic disc,optic fiber layer,optic nerve,outer limiting membrane,peripheral retina,photoreceptor layer,pigment layer,pupil,retina,retinal ganglion cell,retinal ganglion cell layer,retinal inner nuclear layer,retinal inner plexiform layer,retinal layer,retinal neural layer,retinal outer nuclear layer,retinal outer plexiform layer,retinal pigmented epithelium,retinal progenitor cell,retinal progenitor cell region,retinal stem cell,retinal stem cell region,sclera,choroid fissure,eye,eye primordium,iris,optic nerve,optic stalk,optic vesicle

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Experiment details for sox10

Functional analysis of Sox8 during neural crest development in Xenopus.

Functional analysis of Sox8 during neural crest development in Xenopus.

Gene	Clone	Species	Stages	Anatomy
sox10.L		laevis	NF stage 24	optic field

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Fig. 8. Sox8mo-injected embryos have defects in neural crest migration. (A) Phosphohistone H3 immunostaining (α-pH3) shows no difference in the pattern of cell proliferation in stage 17 embryos that received unilateral injection of Sox8mo (left side; FITC label) when compared with the uninjected side. (B) TUNEL staining shows no difference in the pattern of cell death in stage 17 embryos that received unilateral injection of Sox8mo (left side; FITC label) when compared with the uninjected side. In A,B, embryos are viewed from the dorsal side, anterior towards the top. (C) The migration of cranial neural crest cells into the pharyngeal arches visualized by Sox9 and Sox10 expression is severely perturbed in Sox8-depleted embryos (brackets). These cells appear to accumulate lateral to the hindbrain. RNA encoding the lineage tracer β-galactosidase was co-injected to identify the injected side (red staining). Embryos are viewed from the lateral side, anterior towards the left (left panels) or anterior towards the right (right panels). (D) Tissue section of Sox8mo-injected embryos showing accumulation of Sox10-positive cells (small bracket; outlined in red) lateral to the hindbrain on the injected side (arrow); on the control side, Sox10-positive cells have initiated their migration (large bracket; outlined in red). The black outline indicates the position of the hindbrain (hb). (E) TUNEL staining of a stage 25 embryo that received unilateral injection of Sox8mo (left panel; dorsal view, anterior to top). The injected side (arrow) is characterized by reduced pharyngeal arches. Higher power views of the cranial regions on the injected side show no significant increase in TUNEL-positive cells (right panel; lateral view, anterior towards left, dorsal towards top) when compared with the uninjected side (middle panel; lateral view, anterior towards the right, dorsal towards the top).