|
Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
vim
|
|
laevis
|
NF stage 15
to
NF stage 20
|
neuroectoderm
,
neural plate
,
neural tube
|
vim
|
|
laevis
|
NF stage 26
to
NF stage 32
|
brain
,
spinal cord
,
head region
,
branchial arch
,
central nervous system
,
[+]
|
hdac1
|
|
laevis
|
NF stage 15
to
NF stage 20
|
neural crest
,
neural plate
,
neural tube
|
hdac1
|
|
laevis
|
NF stage 26
to
NF stage 32
|
brain
,
spinal cord
,
head region
,
intermediate mesoderm
,
tail bud
,
[+]
|
hdac3
|
|
laevis
|
NF stage 15
to
NF stage 20
|
ectoderm
,
epidermis
,
neuroectoderm
,
neural plate
,
neural tube
|
hdac3
|
|
laevis
|
NF stage 26
to
NF stage 32
|
otic vesicle
,
brain
,
spinal cord
,
head region
,
intermediate mesoderm
,
[+]
|
dnmt1
|
|
laevis
|
NF stage 15
to
NF stage 20
|
neuroectoderm
,
neural plate
,
neural tube
|
dnmt1
|
|
laevis
|
NF stage 26
to
NF stage 32
|
head region
,
intermediate mesoderm
,
tail bud
,
eye
|
zeb2
|
|
laevis
|
NF stage 15
to
NF stage 20
|
neuroectoderm
,
neural plate
,
neural tube
|
zeb2
|
|
laevis
|
NF stage 26
to
NF stage 32
|
midbrain
,
hindbrain
,
spinal cord
,
eye
,
pronephric mesenchyme
|
snai1
|
|
laevis
|
NF stage 15
to
NF stage 20
|
neural crest
|
snai1
|
|
laevis
|
NF stage 26
to
NF stage 32
|
brain
,
branchial arch
,
pharyngeal region
|
sox2
|
|
laevis
|
NF stage 15
to
NF stage 20
|
neuroectoderm
,
neural plate
,
neural tube
|
sox2
|
|
laevis
|
NF stage 26
to
NF stage 32
|
otic vesicle
,
brain
,
forebrain
,
midbrain
,
hindbrain
,
[+]
|
hdac2
|
|
laevis
|
NF stage 26
to
NF stage 32
|
otic vesicle
,
forebrain
,
midbrain
,
hindbrain
,
eye
,
[+]
|
ctnnb1
|
|
laevis
|
NF stage 15
to
NF stage 20
|
neuroectoderm
,
neural plate
,
neural tube
|
cdh2
|
|
laevis
|
NF stage 15
to
NF stage 20
|
neuroectoderm
,
neural plate
,
neural tube
|
cdh2
|
|
laevis
|
NF stage 26
to
NF stage 32
|
otic vesicle
,
forebrain
,
midbrain
,
hindbrain
,
spinal cord
,
[+]
|
ezh2
|
|
laevis
|
NF stage 15
to
NF stage 20
|
neuroectoderm
,
neural plate
,
neural tube
|
ezh2
|
|
laevis
|
NF stage 26
to
NF stage 32
|
brain
,
head region
,
eye
,
pharyngeal region
|
kdm1a
|
|
laevis
|
NF stage 15
to
NF stage 20
|
neuroectoderm
,
neural plate
,
neural tube
|
kdm1a
|
|
laevis
|
NF stage 26
to
NF stage 32
|
brain
,
spinal cord
,
eye
,
central nervous system
|
krt12.4
|
|
laevis
|
NF stage 15
to
NF stage 20
|
epidermis
,
non-neural ectoderm
|
krt12.4
|
|
laevis
|
NF stage 26
to
NF stage 32
|
epidermis
,
eye
,
dorsal fin
,
ventral tail fin
|
cdh1
|
|
laevis
|
NF stage 15
to
NF stage 20
|
epidermis
,
non-neural ectoderm
|
cdh1
|
|
laevis
|
NF stage 26
to
NF stage 32
|
epidermis
,
dorsal fin
,
ventral tail fin
|
|
|
FIGURE 6. The genes involved in tumorigenesis show tissue-specific expression in Xenopus embryos. A, whole mount in situ hybridization (WMISH) detection of expression of genes coding for chromatin modification enzymes. B, WMISH detection of expression of EMT marker genes. Expression of xk81a1 and sox2 is shown as controls. Mid- to late neurula and tailbud embryos were used. Typical expression domains are labeled but the same expression domain in different panels may not be labeled repeatedly. Each embryo is oriented with the anterior to the left. Dorsal view is shown for neurula embryos, and lateral view is shown for tailbud, with dorsal side to the top of each panel. A, anterior; ba, branchial arch; df, dorsal fin; ep, epidermis; ev, ear vesicle; ey, eye; fb, forebrain; hb, hindbrain; he, heart; mb, midbrain; nc, neural crest; np, neural plate; nt, neural tube; P, posterior; pcv, posterior cardinal vein; pl, plexus; pn, pronephros; sc, spinal cord; tb, tailbud. |