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Fig. 3. Three different developmental profiles of gene expression in the intestinal epithelium. Cross sections of the tadpole duodenum are shown at the following stages. (A–C) Premetamorphosis, NF 54. (A′–C′) Metamorphic climax, NF 62. (A′–C′) Postmetamorphosis, NF 66. Sections on slides were hybridized with antisense mRNA probes. (A–A′) Musashi is expressed constitutively in the epithelium before, during, and after metamorphosis. (B–B′) Intestinal fatty acid binding protein is expressed in the epithelium before metamorphosis, and the expression eclipses during climax and returns at the end of metamorphosis. (C–C′) Basic leucine zipper expression is absent before climax, is up-regulated in both the epithelium and mesenchyme during climax, and is down-regulated at the end of climax. (Scale bar:100 μm.) |
