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Figure 4. Patterning of anterior endoderm is perturbed in Staufen2 morpholino injected embryos. Sagittal sections through the anterior endoderm of NF35 control and Staufen2 morpholino injected embryos. a,b:Insulin expression is almost completely abolished (93%, n = 14). Arrowhead in B points to the small remaining insulin expression in the dorsal pancreas. c,d: Expression of PDIp is lost in the future dorsal and ventral anlagen (100%, n = 6). e,f: Expression of frp5 is almost completely lost (100%, n = 7). g,h: Expression of hnf6 is lost (63%, n = 8). dp, dorsal pancreas; vp, ventral pancreas; st/du, stomach/duodenum; li, liver. Reproduced with permission of the Publisher, John Wiley & Sons. |
