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Fig. 2. Developmental expression of C1qR. Anterior is to the left and dorsal to the top unless otherwise specified. (A) Tailbud embryo. Marked expression in the mandibular seg- ment of the neural crest is indicated (ma). Double arrows indicate punctate ventral staining consistent with early vascular precursor expression. Expression in the dorsal cardinal vein is indicated (dcv). (B) Transverse section through the head of embryo in (A) (solid black line). Dorsal is to the top. The developing mesencephalon or mid-brain is labeled (mb). The small arrow to the right of the figure points to mandibular segment expression, dorsal to the developing eye (e). Expression in the head mesenchyme is shown, onsistent with neural crest expression. (C) Section through the trunk of a tailbud embryo (shown in D). Dorsal is to the top. The dorsal cardinal vein is indicated (dcv). Small struc- tures with a lumen in the lateral plate mesoderm (lpm) are consistent with expression in the developing vessels of vitelline network (vvn); (en) endoderm, (n) notochord. (D) Tailbud embryo showing expression throughout the devel- oping vasculature. In addition to the ventral vitelline net- work, both the common (ccv) and the posterior (pcv) cardinal veins show strong expression. There is some expression in the intersomitic veins as indicated by the small arrow. Expression in the branchial arches is labeled (ba). (E) Expression in the vasculature of the larval gut. The reticular pattern of the developing splanchnic vasculature is indicated in the foregut (f) but visible throughout, including in the liver and pancreatic buds. Expression is strongest in the lung bud. (li) liver, (lu) lung, (pa) pancreas. |