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Gene/Clone	Species	Stage	Anatomy Item	Experimenter
baz2b	xenopus		otic placode [+] amphibian papilla,anterior crista,auditory hair cell,auditory ossicle,auditory tube,basilar papilla,endolymphatic duct,footplate of the stapes,inner ear,lagena,lateral crista,middle ear,osseous labyrinth,otic capsule,oval window,pars externa of the stapes,pars interna of the stapes,pars media of the stapes,posterior crista,prootic bone,saccular macula,semicircular canal,stapes,tympanic annulus,tympanic disk,vestibular apparatus,vestibule,auditory apparatus,otic capsule,otic vesicle,vestibulocochlear ganglion

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Experiment details for baz2b

Hooker L et al. (2012) Assay

Microarray-based identification of Pitx3 targets during Xenopus embryogenesis.

Gene	Clone	Species	Stages	Anatomy
baz2b.S		laevis	NF stage 21	otic placode
baz2b.S		laevis	NF stage 31	otic vesicle

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Fig. 7. Characterization of a novel transcript, Baz2b, in X. laevis. A: Protein alignment showing amino acid similarities between Baz2B homologs across organisms. B: Temporal expression of Baz2b throughout embryonic stages of development show expression as a maternal transcript in the egg E and throughout development to tailbud stage, with slight reductions in transcript level at stages 10 and 19. B Confirmation of microarray predictions by means of reverse tran- scriptase-polymerase chain reaction (RT-PCR) show abolished expression at stage 27 in response to Pitx3-morpholino (Pmo) when compared with control-morpholino (Cmo) and wild- type (WT) embryos. C: Baz2b expression at stages 21 (C), 31 (D), and 35 (E) is concentrated in the developing eye, as well as the branchial arches and otic vesicle. Dark expression is seen in the pronephros, persisting in the tubules (E). F: A schematic diagram of Baz2b protein depict- ing various domains characteristic of Baz2B: methyl-CpG binding domain (MBD), DNA binding domain (DDT), zinc finger domain (Z), adjacent to the bromodomain (BR). GenBank accession numbers used to generate phylogenetic tree (A) are as follows: xBaz2b BQ400337 (X. laevis), mBaz2b BC150814 (mouse), rBaz2b NM_001108260 (rat), hBAZ2B NM_013450 (human), cBaz2b NM_204677 (chick), xtBaz2b BC166361 (X. tropicalis).

Gene	Clone	Species	Stages	Anatomy
baz2b.S		laevis	NF stage 21	otic placode

bazb2 (bromodomain adjacent to zinc finger domain, 2B) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 21, lateral view, anterior left, dorsal up.

Gene	Clone	Species	Stages	Anatomy
baz2b.S		laevis	NF stage 31	otic vesicle

bazb2 (bromodomain adjacent to zinc finger domain, 2B) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 31, lateral view, anterior left, dorsal up.