| |
Fig. S6: BMP/Smad1 and Wnt/β-catenin crosstalk.
(A) Overlap between BMP-regulated/Smad1-bound and Wnt-regulated/β-catenin-bound genes.
(B) Browser view of β-catenin and Smad1 peaks in Xenopus and human genes (from
GSM1505734 and GSM1579346). Red boxes indicate overlapping Smad1 and β-catenin peaks.
Black boxes indicate syntenic peaks. (C) In situ hybridization of DMH1, Tg(hsp70:dkk1) and BIO
treated embryos in mid-sagittal section, anterior left and dorsal up. Embryos are either stage
NF12 wild-type or treated at stage NF11 and fixed at stage NF20. * indicates hhex-expressing
FG cells. (D) Expression heatmap of BMP and Wnt ligands and targets present in FG and HG
samples of controls (CO), DMH1, Tg(hsp70:dkk1) and BIO-treated embryos. |
