Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Search Criteria
Gene/CloneSpeciesStageAnatomy ItemExperimenter
wnt11xenopus cement gland 

Too many results?Too few results?

Experiment details for wnt11

Gessert S et al. (2008) Assay

DM-GRASP/ALCAM/CD166 is required for cardiac morphogenesis and maintenance of cardiac identity in first heart field derived cells.

Gene Clone Species Stages Anatomy
wnt11.S laevis NF stage 24 cement gland
wnt11.S laevis NF stage 29 and 30 cement gland

Display additional annotations [+]
  Fig. 2. Expression of DM-GRASP in the FHF of Xenopus laevis. (A) Expression of different cardiac markers as determined by whole mount in situ hybridization at different stages as indicated. Arrows indicate cardiac progenitor cell population at stage 20, first heart field (FHF) at stage 24 and cells of the developing primary heart tube (PHT) at stage 29. Arrowheads indicate second heart field (SHF) at stage 24 and 29. The cement gland is highlighted by a dotted line. (B) Schematic representation of the location of cardiac progenitor cells, first heart field (FHF), second heart field (SHF) and forming primary heart tube (PHT) with the corresponding marker genes. DM-GRASP is not expressed in the cardiac progenitor cell population but in the FHF and the forming PHT at later stages. Note that at this stage, the linear heart tube has not yet formed.

Gene Clone Species Stages Anatomy
wnt11.S laevis NF stage 28 cement gland

Display additional annotations [+]
  Fig. 5. Loss of DM-GRASP affects marker gene expression in the FHF but not the SHF. (A) DM-GRASP MO was unilaterally injected at the 8-cell stage and expression of cardiac marker genes was monitored at stage 20. No changes for Tbx20, Isl-1 and Nkx2.5 could be detected. Anterior views of whole embryos are given. (B) DM-GRASP MO was unilaterally injected at the 8-cell stage and expression of cardiac marker genes as indicated was monitored at stage 28. Loss of DM-GRASP resulted in down-regulation of some marker genes of the FHF (arrows) but not SHF such as Isl-1 or BMP-4. Ventral views of embryos are given. (C) Quantitative presentation of observed phenotype in panel B. Error bars are standard errors of the means. N = number of examined embryos, n = number of independent experiments.