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vangl2xenopus involuting marginal zone epithelial layer [+] 

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Experiment details for vangl2

Ossipova O et al. (2015) Assay

Vangl2 cooperates with Rab11 and Myosin V to regulate apical constriction during vertebrate gastrulation.

Gene Clone Species Stages Anatomy
vangl2.L laevis NF stage 10 involuting marginal zone epithelial layer

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  Fig. S1. Immunodetection of endogenous Vangl2 protein. (A, B) Basolateral localization (arrowhead) of Vangl2 (A) and b1-integrin (B) in embryonic ectoderm at stage 11. (C) Immunoblot of ectodermal cell lysates with anti- Vangl2 antibody reveals a 60 kDa band (arrowhead) corresponding to endogenous Vangl2, misexpressed Xenopus CFP-Vangl2 and mouse HA-VL2, as indicated.(D-G) Vangl2 immunostaining on cross-sections of st. 10- and st. 10.5 embryos. Dashed boxes in D and E correspond to the magnified images shown in D’ and E’. Vangl2 is detected at the basolateral membrane and in cytoplasmic vesicles near the apical cortex, and appears more abundant in the superficial cell layer. Scale bar in A is 20 μm. Both apical (arrow) and basolateral staining is detected in the constricting blastopore cells of st. 10.5 embryo. D-G, Scale bar is 20 μm.