| Search Criteria |
| Gene/Clone | Species | Stage | Anatomy Item | Experimenter |
|---|---|---|---|---|
| tnni3 | xenopus |
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Experiment details for tnni3
Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory...Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5.
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| Double-sided injection of a dominant inhibitory tinman construction can completely eliminate myocardial differentiation. Lateral view of control and experimental stage 30 embryos. The top embryo was injected with water and shows normal expression of TnIc in the developing heart tube. The bottom embryo was injected on each side with 125 pg of Nkx2-5LP mRNA. No expression of the TnIc myocardial marker is visible. Note that the overall morphol- ogy of both the control and experimental embryos is normal |