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Fig. 4. BMP inhibition together with FGF8a does not induce neural marker expression in Xenopus. (A–B) Injection of FGF8a into one cell at the two-cell stage does not alter Brachyury expression at the gastrula stage (A) but does expand β-tubulin expression at the neurula stage (B); arrowheads indicate the injected side. (C–F) Injection of FGF8a into an A4 blastomere, alone (C, D) or in combination with the BMP inhibitor Smad6 (E, F) does not induce Sox3 expression in ventral epidermis. A: vegetal view; B, C and E are dorsal views; D and F are ventral views of the embryos to their left. Black squares show the area enlarged in the inset in panels D and F. |
