Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Search Criteria
Gene/CloneSpeciesStageAnatomy ItemExperimenter
tbxtxenopus   

Too many results?Too few results?

Experiment details for tbxt

Nagel M et al. (2004) Assay

Guidance of mesoderm cell migration in the Xenopus gastrula requires PDGF signaling.

Gene Clone Species Stages Anatomy
tbxt.S laevis NF stage 10 mesoderm , marginal zone , involuting marginal zone
tbxt.S laevis NF stage 11.5 marginal zone , involuting marginal zone , involuted dorsal mesoderm , axial mesoderm

Display additional annotations [+]
  Fig. 6. Effect of compromised PDGFA signaling on mesoderm movement. (A-R) In situ hybridization. Expression of Xbra at stage 10 (A-C) and stage 11.5 (G-J), and of chordin at stage 10 (D-F) and stage 11.5 (K-N), in uninjected embryos (A,D,G,K), and in embryos injected with dnPDGFA (B,E,H,L) or lfPDGFA mRNA (C,F,I,M) or PDGF morpholino (J,N). (A-C) Vegetal view. (D-N) Dorsovegetal view with animal towards the top. Brackets indicate extending notochord region. (O-R) Expression of gsc in controls (O), and in dnPDGFA (P), lfPDGFA (Q) and PDGF morpholino (R) gastrulae fixed at stage 12 and fractured mid-sagittally. Small arrowhead, blastopore lip; large arrowhead, tip of archenteron; arrow, gsc expression. (S-V) Convergent extension in dorsal blastopore lips explanted at stage 10 from control (S), dnPDGFA expressing (T), lfPDGFA overexpressing (U) and PDGF morpholino injected (V) gastrulae, fixed at stage 14 (n=15, three independent experiments for each treatment).