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Fig. 5. Blastopore closure and neural fold formation in XDppaMO injected embryos are rescued by mDppa2. The open blastopore and the lack of neural fold formation caused by XDppaMO are rescued by co-injection of mDppa2 mRNA giving rise to normal embryos. The wild type expression pattern of markers Xbra (ventral view), Chordin and XSox2 (dorsal view), which are delocalised or downregulated after loss of function, is restored at stage 17. Unmanipulated embryos and embryos injected with ctrlMO are shown as neurulating wild type controls (left columns). |
