| Search Criteria |
| Gene/Clone | Species | Stage | Anatomy Item | Experimenter |
|---|---|---|---|---|
| sox3 | xenopus |
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Experiment details for sox3
Linker C et al. (2009) AssayCell communication with the neural plate is required for induction of neural markers by BMP inhibition: evidence for homeogenetic induction and implications for Xenopus animal cap and chick explant assays.
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| Fig. 3. BMP inhibition together with eFGF activation induces neural marker expression indirectly in Xenopus. (A–L) Inhibition of BMP by injection of Smad6 into the A4 blastomere does not induce either Sox3 (A, B) or Sox2 (C, D) expression. eFGF together with BMP inhibition into the A4 blastomere induces Sox3 (E, F, N) and Sox2 (G, H, O). Neural induction by the former combination is inhibited when Nodal signaling is blocked: injection of Smad6 + eFGF together with CerS no longer induces Sox3 (I, J) or Sox2 (K, L). (M) Quantification of Sox3 and Sox2 expression in the different experiments described above. A, C, E, G, I and K dorsal views. B, D, F, H, J and L ventral views of the embryos to their left. N and O are enlargements of the areas enclosed by a square in F and H, respectively. | |||||||||||
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| Fig. 4. BMP inhibition together with FGF8a does not induce neural marker expression in Xenopus. (A–B) Injection of FGF8a into one cell at the two-cell stage does not alter Brachyury expression at the gastrula stage (A) but does expand β-tubulin expression at the neurula stage (B); arrowheads indicate the injected side. (C–F) Injection of FGF8a into an A4 blastomere, alone (C, D) or in combination with the BMP inhibitor Smad6 (E, F) does not induce Sox3 expression in ventral epidermis. A: vegetal view; B, C and E are dorsal views; D and F are ventral views of the embryos to their left. Black squares show the area enlarged in the inset in panels D and F. |