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Figure 6. Eye-specific marker genes are unaffected upon loss of Sox4 or Sox11 function.A and B: Depletion of Sox4 function had no influence on marker gene expression at stage 13. Loss of Sox11 led to a slight decrease of pax6 expression. C and D: At stage 23, Sox4 depleted embryos revealed a reduced expression of rax, pax6, sox3 and en2. Emx1 and egr2 expression was not affected. In contrast, all marker genes were mildly affected upon Sox11 knock-down. B and D. Quantitative representations are given. n = number of independent experiments, N = number of injected embryos analyzed, n.s. = not significant, * P≤0.05,** P≤0.01. |
