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sox2xenopus   

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Experiment details for sox2

Galli A et al. (2003) Assay

Glypican 4 modulates FGF signalling and regulates dorsoventral forebrain patterning in Xenopus embryos.

Gene Clone Species Stages Anatomy
sox2.L laevis NF stage 10.5 neuroectoderm outer layer , neuroectoderm inner layer

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  Fig. 1. Gpc4 expression during early development of Xenopus embryos. Arrowheads (B-F) point to the dorsal blastopore lip. (A) Blastula (stage 7) showing localization of Gpc4 transcripts in the animal hemisphere. AP, animal pole; VP, vegetal pole. (B) Expression of Gpc4 at the onset of gastrulation (stage 10). (C) Dorso-vegetal view of an early gastrula stage embryo (stage 10.5). The broken line indicates the plane of the hemi-sections shown in panels D-F and I. (D-F) Hemi-sections of embryos cut along the dorsoventral axis (stage 10.5). (D) Gpc4 transcripts in prechordal endomesoderm and chordamesoderm (asterisk) and in the neuroectodermal cell layer (arrow). (E) Distribution of Noggin transcripts in the prechordal endomesoderm and chordamesoderm (asterisk). (F) Sox2 in the neuroectodermal cell layer (arrow). (G) Frontal view of an early neural plate embryo (stage 14). Note Gpc4 transcripts in the anterior neural plate (black arrow) and presumptive spinal cord (white arrow). (H) Frontal view of a stage 14 embryo showing Bf1 expression in the anterior forebrain. (I) Expression of Gpc4 in a hemi-sectioned embryo (stage 14). Anterior is to the left. The white arrowhead points to decreasing expression in the prechordal plate. (J) Frontal view of a mid-neurula (stage 17). Asterisks point to Gpc4 transcripts in the presumptive dorsal forebrain. (K) Emx2 expression in the presumptive dorsal forebrain (stage 17; asterisks). (L) Expression of Gpc4 following closure of the anterior neural tube (stage 20). Arrow points to transcripts in the forebrain.

Gene Clone Species Stages Anatomy
sox2.L laevis NF stage 12 neuroectoderm

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  Fig. 3. Changes in gene expression become apparent during gastrulation of GPC4-depleted embryos. Dorso-vegetal view of embryos injected with CoMo (A,C,E,G,I) and Gpc4Mo (B,D,F,H,J). Arrowheads in panels A-D and G-J indicate the blastopore lip. Anterior is to the top. (A-D) Gsc expression during gastrulation (stage 10 to 10.5). (E,F) Xbra expression during late gastrulation (stage 12). (E) Expression in the developing notochord (No) in control embryos. Arrow in F indicates reduced length of notochord expression in GPC4-depleted embryos. (G,H) Noggin transcripts at stage 12. Asterisk indicates anterior-most expression. Bar indicates length of expression domain in the presumptive notochord. Noggin transcripts are normal in the anterior mesendoderm (asterisk), but the length of the presumptive notochord is reduced in GPC4-depleted embryos (compare G with H). (I,J) Sox2 expression in neuroectoderm (Ne) at stage 12. Sox2 is not expressed in the posterior midline of control embryos (asterisk in I), and Sox2 expression is not excluded from posterior midline in Gpc4Mo-injected embryos (asterisk in J). (K,L) Frontal view of Et expression (stage 21) to show that two retina fields form in CoMo-(K) and Gpc4Mo-injected embryos (L).