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Supplementary Figure 8. Activin/Nodal signaling is required for proper neural tissue formation in Xenopus. a, Expression of foxD5 at stage 13, N-tubulin at stage 15 and sox2 at stage 13 (left) and stage 25 (right) in control embryos and in embryos treated with 200µM SB505124 from midgastrula stage 11. Note the decreased intensity of neural marker gene expression in SB505124-treated embryos. Dorsal view for foxD5, N-tubulin and sox2 at stage 13 and stage 25 (right) and lateral view for sox2 at stage 25 (left). b, Expression of chd, myoD and sox2 at early neurula stage 14 in control embryos and in embryos treated with 800µM SB431542 from stage 11. Note the reduced neural plate in SB431542-treated embryos despite normal axial and paraxial mesoderm formation. Dorsal view for chd, myoD and sox2 (left), and anterior view for sox2 (right). Scale bar, 200µm. |
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sox2 (SRY box 2) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 25, lateral view, anterior left, dorsal up. |
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sox2 (SRY box 2) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 25, dorsal view, anterior left. |
