| Search Criteria |
| Gene/Clone | Species | Stage | Anatomy Item | Experimenter |
|---|---|---|---|---|
| sox10 | xenopus |
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Experiment details for sox10
SoxE factors function equivalently during neural crest and inner ear development and their activity is regulated by SUMOylation.SoxE factors function equivalently during neural crest and inner ear development and their activity is regulated by SUMOylation.
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| Figure 2. Sox9 and Sox10 Rescue Neural Crest Development in Sox10-Depleted EmbryosEmbryos injected with Sox10 morpholinos (MO) show reduced or absent expression of early neural crest markers such as Sox10 (A and B) and reduced otic vesicles and cranial neural crest (G and H). These defects could be rescued equally well by Sox9 or Sox10 (C–F and I–L). Sox9 retains its ability to induce ectopic melanocytes in Sox10-depleted embryos (J, black arrows). Light red stain is the lineage tracer β-gal. | |||||||||||
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| Figure 3. Sox9 and Sox10 Induce Enlarged and Ectopic Ear Structures(A–F) In situ hybridization showing Sox10 expression in the ears of stage 28 embryos injected with Sox9 (A and C) or Sox10 (B, D, and F). Expression of either of these factors consistently leads to the formation of enlarged ears (A and B, white arrows) and/or to the formation of one or more ectopic ears (C, D, and F, black arrowheads).(G and H) Increased expression of Pax8, which marks the otic placode (white arrowhead) in Sox9- (G) or Sox10- (H) injected embryos at stage 13. Light blue or red stain is the lineage tracer β-gal. |