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Experiment details for shh

Rankin SA et al. (2012) Assay

Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus.

Gene Clone Species Stages Anatomy
shh.L laevis NF stage 33 and 34 to NF stage 35 and 36 endoderm , pharyngeal arch , mandibular arch , hyoid arch , branchial arch , [+]

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  Fig. 3. Osr1/Osr2 are required for wnt2b and raldh2 expression in the lpm. (A-X) Analysis of stage 34/35 unilateral-injected embryos shows that Osr1/Osr2 are required for expression of nkx2.1 (A-C) and sox2 (D-F) in the epithelium, whereas shh (G-I) is unaffected. In the lpm, wnt2b (J-L) and raldh2 (M-O) are absent, while foxf1 is unaffected (P-R). Black arrows indicate normal expression on the control side and red arrows indicate lack of expression on the Osr1/Osr2-MO-injected side (right). Endoderm outlined by a yellow line. Numbers of embryos with the shown phenotype are indicated. fg, foregut; hg, hindgut; de, dorsal endoderm; pe, posterior endoderm; e, esophagus; l/t, presumptive lung and trachea; lv, liver; lpm, lateral plate mesoderm; k, kidney; s, stomach.

Gene Clone Species Stages Anatomy
shh.L laevis NF stage 33 and 34 to NF stage 35 and 36 brain , forebrain , diencephalon , hindbrain , spinal cord , [+]

  shh (sonic hedgehog) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 34/35, lateral view, anterior left, dorsal up.