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Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
foxf1
|
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laevis
|
NF stage 33 and 34
to
NF stage 35 and 36
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head region
,
pharyngeal arch
,
lateral plate mesoderm
,
anterior dorsal lateral plate region
,
olfactory region
|
sox2
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laevis
|
NF stage 33 and 34
to
NF stage 35 and 36
|
otic vesicle
,
brain
,
spinal cord
,
endoderm
,
pharyngeal arch
,
[+]
|
nkx2-1
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laevis
|
NF stage 33 and 34
to
NF stage 35 and 36
|
brain
,
forebrain
,
endoderm
,
trachea
,
lung
,
[+]
|
wnt2b
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|
laevis
|
NF stage 33 and 34
to
NF stage 35 and 36
|
otic vesicle
,
pharyngeal arch
,
pineal gland
,
lens placode
,
lateral plate mesoderm
|
aldh1a2
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|
laevis
|
NF stage 33 and 34
to
NF stage 35 and 36
|
otic vesicle
,
lens
,
brain
,
midbrain
,
hindbrain
,
[+]
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Fig. 3. Osr1/Osr2 are required for wnt2b and raldh2 expression in the lpm. (A-X) Analysis of stage 34/35 unilateral-injected embryos shows that Osr1/Osr2 are required for expression of nkx2.1 (A-C) and sox2 (D-F) in the epithelium, whereas shh (G-I) is unaffected. In the lpm, wnt2b (J-L) and raldh2 (M-O) are absent, while foxf1 is unaffected (P-R). Black arrows indicate normal expression on the control side and red arrows indicate lack of expression on the Osr1/Osr2-MO-injected side (right). Endoderm outlined by a yellow line. Numbers of embryos with the shown phenotype are indicated. fg, foregut; hg, hindgut; de, dorsal endoderm; pe, posterior endoderm; e, esophagus; l/t, presumptive lung and trachea; lv, liver; lpm, lateral plate mesoderm; k, kidney; s, stomach. |
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shh (sonic hedgehog) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 34/35, lateral view, anterior left, dorsal up.
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