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Fig. 1. Ontogeny and hematopoietic potential of the anterior portion of the ventral blood island (aVBI). (A) The aVBI and its precursor, the embryonic hemangioblasts, derive from dorsal blastomeres of the 32-cell stage embryo. (B) Embryonic hemangioblast (red cells) are specified during gastrulation when their mesodermal precursors (blue cells) encounter BMP signalling during their migration from dorsal to ventral. (C) Erythroid (Runx1) and myeloid (SpiB) genes are co-expressed (red arrows) at the hemangioblast stage. (D) Numerous myeloid cells differentiate from the embryonic hemangioblast at tail bud stages. These myeloid cells are highly migratory and initiate migration at stage 22 (24 hpf arrowheads). |
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Fig. 4. Ontogeny of the dorsal aorta (DA) and hematopoietic stem cells (HSCs) in Xenopus. (A) Runx1 expression and HSC emergence is restricted to the DA encompassing the trunk. (B) The DA is anatomically subdivided into paired DA, trunk DA and tail artery. HSCs only emerge in the trunk DA. (C) Diagram summarizing the blastomere origins of the anatomical subdivision of the DA. |
