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pax8xenopus   

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Experiment details for pax8

Urban AE et al. (2006) Assay

FGF is essential for both condensation and mesenchymal-epithelial transition stages of pronephric kidney tubule development.

Gene Clone Species Stages Anatomy
pax8.L laevis NF stage 28 pronephric mesenchyme , pronephric nephron , pronephric kidney

  Fig. 10. Inhibition of FGF8 translation leads to retention of the pronephric mesenchymal marker Pax8 but blocks activation of the pronephric epithelial marker Na+K+ ATPase. (A–C) Pax8 expression on the contralateral control (A) and FGF8-MO-injected (B, C) sides of an embryo. The morpholino results in pronephric cells retaining Pax8 expression and appearing to be mesenchymal. (D–F) FGF8-MO blocks expression of the epithelial marker Na+K+ ATPase on the injected side of the embryo (Table 4).