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pax6xenopus   

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Experiment details for pax6

FMR1/FXR1 and the miRNA pathway are required for eye and neural crest development.

FMR1/FXR1 and the miRNA pathway are required for eye and neural crest development.

Gene Clone Species Stages Anatomy
pax6.L laevis NF stage 13 neuroectoderm , neural crest , eye primordium , anterior neural fold
pax6.L laevis NF stage 23 olfactory placode , neuroectoderm , neural crest , eye primordium

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  Fig. 2. FMR1 interferes with late eye and NC cell development. A. Injection of FMR1 and Control MO had no effect on the expression of neural marker genes at stages 13 and 17. B. FMR1 deficient embryos showed a reduced expression of eye marker genes Rx1 and Pax6 on the injected side (arrows) at stage 23. A quantitative representation is given. C. Inhibition of FMR1 resulted in defects in NC cell migration at stage 20 (FoxD3 expression, arrow) and stage 23 (expression of Krox20 and Twist, arrows). The red brackets highlight the difference of migrating Krox20-positive NC cells between uninjected and FMR1 MO injected sides. A quantitative presentation is shown. n = number of independent experiments; N = number of analyzed embryos.