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pax3xenopus   

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Experiment details for pax3

Nkx6 genes pattern the frog neural plate and Nkx6.1 is necessary for motoneuron axon projection.

Nkx6 genes pattern the frog neural plate and Nkx6.1 is necessary for motoneuron axon projection.

Gene Clone Species Stages Anatomy
pax3.S laevis NF stage 16 neuroectoderm , neural plate , anterior neural fold

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  Fig. 2. Effect of Nkx6 mRNA injection on neural development. Gene expression patterns analyzed by whole mount in situ hybridization. Top row: uninjected control embryos. Middle row: embryos injected with Nkx6.1 mRNA. Bottom row: embryos injected with Nkx6.2 mRNA. Injected side is to the right and red stain indicate beta-galactosidase lineage tracer. All embryos are analyzed at stage 16, except embryos stained for Pax3 (V–X), which were analyzed at stage 17. (A–C) Pan-neural marker Nrp1 is expanded in Nkx6 injected embryos. (D–F) Epidermal marker cytokeratin-81 (CK81) is reduced in Nkx6 injected embryos. (G–I) Primary neurogenesis is inhibited by Nkx6 mRNA injected as visualized by loss of N-tubulin (N-tub) staining. (J–L) Dbx1 expression is inhibited in the spinal neural plate when embryos are injected with Nkx6 mRNA. (M–O) Spinal neural plate expression of Pax2 is repressed by Nkx6 mRNA, whereas the MHB is intact. (P–R) Spinal, but not rhombomeric, expression of Irx3 is repressed by Nkx6 misexpression. (S–U) Pax6 expression in the neural plate is repressed by ectopic Nkx6 misexpression. (V–X) Pax3 expression and Msx1 (Y–æ) expression is unchanged in response to Nkx6 injection.