Gene Expression Search Experiment

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Gene/Clone	Species	Stage	Anatomy Item	Experimenter
pard3	xenopus		neural crest [+] afferent neuron,anterior branchial crest,efferent neuron,enteric neuron,interneuron,peripheral nerve,posterior branchial crest,afferent neuron,anterior branchial crest,branchial crest,efferent neuron,enteric nervous system,enteric neuron,glial cell,melanoblast,melanophore,migratory neural crest cell,peripheral ganglion,posterior branchial crest

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Experiment details for pard3

Par3 controls neural crest migration by promoting microtubule catastrophe during contact inhibition of locomotion.

Gene	Clone	Species	Stages	Anatomy
pard3.S		laevis	NF stage 20	neural crest

Fig. 6. Par3 is localised at the contact site of Xenopus NC cells and does not affect stable microtubules. (A-F) Par3GFP localises to contacts between NC cells in clusters (A) and between colliding single cells (B). (C-F) z-projection of confocal images showing immunostaining against endogenous Par3 in cryosections of Xenopus embryos. (C) Par3 is located at contacts between NC cells. (D) mbRFP identifies NC cells and cell contacts; each asterisk indicates a different cell. (E) Merge of I and J. (F) Colocalisation mask of I and J. (G-J) Analysis of microtubules in NC cells. (G,H) Immunostaining against α-tubulin shows the microtubule array in ControlMO-injected (G) and Par3MO-injected (H) cells. (I,J) Immunostaining against acetylated tubulin stains a stable subpopulation of microtubules in ControlMO-injected (I) and Par3MO-injected (J) cells. Scale bars: 10 μm in A; 20 μm in C.