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Figure 5. Staufen2 is required for the earliest stages of endoderm regionalization. a: Transverse section through the embryo at NF18. a,b:Sox17β expression by whole mount in situ hybridization in control and Staufen2-MO-injected embryos, expression of sox17β remains unchanged throughout the endoderm (80%, n = 20). c,d: Expression of gata4 is lost in the anterior endoderm (82%, n = 17). e,f: Expression of hnf6 is lost in the anterior endoderm (67%, n = 9). g,h: Expression of hex is almost completely lost (72%, n = 18). Brackets identify anterior endoderm. Reproduced with permission of the Publisher, John Wiley & Sons. |
