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nphs1xenopus   

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Experiment details for nphs1

Notch signaling, wt1 and foxc2 are key regulators of the podocyte gene regulatory network in Xenopus.

Notch signaling, wt1 and foxc2 are key regulators of the podocyte gene regulatory network in Xenopus.

Gene Clone Species Stages Anatomy
nphs1.S laevis NF stage 35 and 36 glomus , pronephric kidney , podocyte

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  Fig. 1. Spatiotemporal expression of podocyte genes. (A-A′) Schematics depicting the glomus (black) in whole Xenopus embryos (A) and in transverse section at low (A′) and high (A′) magnification at stage 35. (B-J′) In situ hybridization of podocyte transcription factors wt1 (B-B′), foxc2 (C-C′), tcf21 (D-D′), mafb (E-E′) and lmx1b (F-F′) and of markers of podocyte differentiation kirrel (G-G′), nphs1 (H-H′), ptpru (I-I′) and nphs2 (J-J′) at stage 35 in whole-mounts (B-J) and transverse sections (B′-J′). (K) Temporal profile of podocyte gene expression in the glomus. en, endoderm; g, pronephric glomus; lpm, lateral plate mesoderm; no, notochord; nt, neural tube; so, somites; t, pronephric tubules.