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nkx2-5xenopus   

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Experiment details for nkx2-5

Cardiac neural crest is dispensable for outflow tract septation in Xenopus.

Cardiac neural crest is dispensable for outflow tract septation in Xenopus.

Gene Clone Species Stages Anatomy
nkx2-5.L laevis NF stage 25 heart , cardiac mesoderm , heart primordium , primary heart field , secondary heart field , [+]
nkx2-5.L laevis NF stage 29 and 30 myocardium , cardiac mesoderm , primary heart field , secondary heart field
nkx2-5.L laevis NF stage 33 and 34 heart , myocardium , primary heart field , secondary heart field
nkx2-5.L laevis NF stage 35 and 36 heart , cardiac ventricle , outflow tract

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  Fig. 3. Molecular characterization of the primary and second heart fields. (A-U) Developmental expression of Nkx2.5, Tbx5 and Tbx20 at stages 25, 30, 33 and 35 as indicated. The horizontal lines indicate the predicted position of primary heart field (PHF) and second heart field (SHF). All three genes are detected in the PHF, whereas the SHF expresses both Nkx2.5 and Tbx20 but is negative for Tbx5 expression. At later stages, the developing outflow tract (OFT), a derivative of the SHF, remains Tbx5 negative. (A,C,E,G,I,K,M-U) Lateral views, anterior to right. (B,D,F,H,J,L) Ventral views, anterior to top. V, ventricle. Scale bars: 100 μm.