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nkx2-5xenopus   

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Experiment details for nkx2-5

Gessert S and Kühl M (2009) Assay

Comparative gene expression analysis and fate mapping studies suggest an early segregation of cardiogenic lineages in Xenopus laevis.

Gene Clone Species Stages Anatomy
nkx2-5.S laevis NF stage 13 mesoderm , ventral , anterior , cardiac progenitor cell

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  Fig. 1. Whole mount in situ hybridization of Xenopus laevis embryos at stage 13. The expression of Isl1, Nkx2.5, GATA6b, Tbx1, and FGF8b is given. Anterior views (upper row) of embryos are shown. Dashed lines indicate the level of sagittal sections shown in the lower row. e, endoderm; ect, ectoderm; m, mesoderm.

Gene Clone Species Stages Anatomy
nkx2-5.S laevis NF stage 15 to NF stage 20 lateral plate mesoderm , cardiac progenitor cell
nkx2-5.S laevis NF stage 24 to NF stage 29 and 30 heart , heart primordium , posterior

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  Fig. 2. (A) Cardiac expression of Isl1, Nkx2.5, GATA4, GATA5, GATA6b, Xmsr and Flk1 in Xenopus embryos at stages 15/16, 20, 24 and 29 as indicated. (B) Cardiac expression of Tbx20, Tbx1, Tbx5, BMP2, BMP4, Dkk1, and FGF8b at different developmental stages of Xenopus laevis as indicated. For embryos at stages 15/16 and 20 anterior views are presented, whereas embryos at stage 24 and 29 are shown from the ventral side, anterior is to the top. Dotted lines indicate the cement gland.

Gene Clone Species Stages Anatomy
nkx2-5.S laevis NF stage 29 and 30 to NF stage 31 heart , myocardium

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  Fig. 6. (A) Serial transverse sections indicate the expression of Isl1, Nkx2.5, GATA4, GATA5, GATA6b, Xmsr and Flk1 in Xenopus laevis embryos at stage 30/31. (B) Spatial expression of Tbx20, Tbx1, Tbx5, BMP2, BMP4, Dkk1 and FGF8b at stage 30/31. The upper row provides a lateral view. Dashed lines depict the level of sections A, B and C as indicated. Level A corresponds to the anterior region of the heart. Level B is at the level of the closing heart tube. Level C is at the posterior end of the heart where the IFT forms later in development.