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myod1xenopus   

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Experiment details for myod1

Hypaxial muscle migration during primary myogenesis in Xenopus laevis.

Hypaxial muscle migration during primary myogenesis in Xenopus laevis.

Gene Clone Species Stages Anatomy
myod1.S laevis NF stage 26 somite , paraxial mesoderm , trunk somite , trunk
myod1.S laevis NF stage 28 to NF stage 29 and 30 mesoderm , somite , paraxial mesoderm , trunk somite
myod1.S laevis NF stage 31 somite , muscle , otic placode , lens placode , epibranchial placode , [+]
myod1.S laevis NF stage 41 somite , muscle , ventral , head , hypaxial muscle

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  FIG. 2. Expression patterns of the myogenic transcription factors pax3, myf-5, and myoD. Upregulation of pax3 in the dorso-lateral lip of the anterior trunk somites is apparent at stage 26 (A, arrows). By stage 28/29 pax3-positive cells can be seen leaving the somites and migrating ventrally (B, arrows). At stage 37/38, pax3 cells can be seen at the front of the migration (D) as they continue to stream out of the somites (D, arrow head). Stage-41 embryos have faint pax3 expression at the front of the migrating cells (E, arrows). Early myf-5 expression is restricted to the dorso-medial and ventro-lateral lips of the somites, marking the expanding epaxial myotome (F, G). At stage 31 (H, arrows), myf-5-expressing cells can clearly be seen outside of the somitic region migrating ventrally, and continuing to do so through stages 37/38 (I) and 41 (J, arrows). Expression of myoD is present only in the somitic region (K) until stage 37/38 (N), when it appears in discrete patches clearly separate from the somites (arrows). By stage 41, there are long stripes of myoD expression corresponding to the differentiated ventral body wall muscle (O). Expression is greatest in the ventral-most region of the body wall, where skeletal muscle has most recently differentiated.

Gene Clone Species Stages Anatomy
myod1.S laevis NF stage 37 and 38 to NF stage 41 muscle , hypaxial muscle , epaxial muscle

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  FIG. 3. Embryos stained for either pax3 (A) or myoD (E) followed by 12/101 staining. Stage-37 embryos stained for pax3 expression (A, B) reveal the pax3-expressing cells are just ventral to differentiated muscle (arrow heads), with little overlap, as indicated from a transverse section (B) of embryo in (A) (arrow). The lack of overlap is more dramatic in stage-41 embryos (C, arrow). (D) A transverse section of embryo in (C). The arrow shows pax3 expression which does not overlap with 12/101 staining (arrow heads). Stage-37 embryos stained formyoD (E, F) indicate significant overlap ofmyoD expression and differentiatedmuscle (arrow heads in E, arrow in F). At stage 41, overlap of myoD expression continues over a broad range of differentiated muscle (G), which can also be seen in (H) (arrows). In (B), (D), (F), and (H), dorsal is toward the top of the page.