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mxi1xenopus   

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Experiment details for mxi1

Arima K et al. (2005) Assay

Global analysis of RAR-responsive genes in the Xenopus neurula using cDNA microarrays.

Gene Clone Species Stages Anatomy
mxi1.L xl043c08 laevis NF stage 18 pre-chordal neural plate , chordal neural plate , eye primordium , neural plate , cranial placode
mxi1.L xl043c08 laevis NF stage 22 olfactory placode , brain , forebrain , midbrain , hindbrain , [+]

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  Figure 4. Expression patterns of selected retinoic acid receptor (RAR) target genes. Expression pattern of selected upregulated genes at stage 18 and stage 22 were determined by whole-mount in situ hybridization. Embryos were hybridized with probes made from indicated expressed sequence tag (EST) clones. The staining patterns in whole and sectioned embryos were summarized and used to categorize the genes broadly into four groups (group 1, 2, 3, and 4) by expression patterns. The signature staining of group 1 is present in the neural tube, neural crest, and optic anlagen; the staining patterns of group 2 are similar to those of group 1 but absent from the neural crest. Group 3 genes show staining in the neural tube but not in the optic anlagen. Group 4 genes have staining in the lateral plate mesoderm where RALDH2 is predominantly expressed. A, B, and C are in group 1; D, E, and F are in group 2; G, H, and I are in group 3; and J, K, and L are in group 4. A1-L1, A3-L3, M1-R1, and M2-R2: dorsal view; A2-I2 and A4-I4: anterior view; C6 and J2-L2: lateral view; C7: ventral view; C5: J4-L4 and M3-R3: sagittal section of stage 22 embryos. VLCS, very-long-chain acyl-CoA synthetase; Hypothetical, similar to ESTs from other organisms; Unidentified, no significant similarity to database sequences from any organism; Sm, somites; rp, roof plate of the neural tube; no, notochord; nt, the neural tube.

Gene Clone Species Stages Anatomy
mxi1.L xl043c08 laevis NF stage 18 stomodeal-hypophyseal primordium , chordal neural plate , neural plate , cranial placode

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  Fig. 5. The effects of modulated retinoid signaling on expression pattern of retinoic acid receptor (RAR) target genes. The effects of AGN 193109, TTNPB, or vehicle control on expression pattern of three expressed sequence tags (ESTs), XL016p20 (S1�S6), XL049b08 (T1�T6), and XL043c08 (U1�U6), were determined in stage 18 embryos by whole-mount in situ hybridization. AGN193109 treatment reduced posterior neural expression of all three genes compared with controls (S1 vs. S2, T1 vs. T2, and U1 vs. U2) but increased medial staining of XL016p20 (S1 vs. S2), XL049b08 staining in the eye anlagen (T4 vs. T5), and XL043C08 expression in the forebrain (U1 vs. U2). In contrast, TTNPB treatment increased expression of XL016P20 throughout the embryo (S3, S6 vs. S2, S5) and reduced Xl043C08 staining in the forebrain and presumptive trigeminal ganglion (U3, U6 vs. U2, U5). S1�S3, T1�T3, and U1�U3: dorsal view; S4�S6, T4�T6, and U4�U6: anterior view; TTNPB, TTNPB-treated embryos; Control, vehicle control embryo; AGN193109, AGN193109-treated embryos.