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Experiment details for mmp7

Agricola ZN et al. (2015) Assay

Identification of genes expressed in the migrating primitive myeloid lineage of Xenopus laevis.

Gene Clone Species Stages Anatomy
mmp7.L image:5572538 laevis NF stage 15
mmp7.L image:5572538 laevis NF stage 19 anterior ventral blood island , myeloid cell
mmp7.L image:5572538 laevis NF stage 24 anterior ventral blood island , myeloid cell
mmp7.L image:5572538 laevis NF stage 28 head , anterior ventral blood island , myeloid cell

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  Figure 1. Stage 15, 19, 24, and 28 expression of identified genes progress from anterior ventral blood island to dispersed distribution. They are temporally downstream of transcriptional regulators spib.a (A–A‴) but coincident with other, later expressing myeloid functional genes like mmp7 (B–B‴). C–C‴, adam28. D–D‴, coro1a. E–E‴, ctss. F–F‴, dstn. G–G‴, fmnl1. H–H‴, ptpn6. I–I‴, timp-1. White scale bar = 1 mm.

Gene Clone Species Stages Anatomy
mmp7.L image:5572538 laevis NF stage 21 anterior ventral blood island , myeloid cell

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  Figure 4. Animal cap-injected X.t. cebpa mRNA induces exogenous myeloid gene expression in Stage 21 X.l. embryos. A–J: Uninjected embryos ventral view. A′–J′: 200 pg cebpa and 300 pg gfp mRNA coinjected embryos ventral view. A, A′: spib.a. B, B′: mpo. C, C′: mmp7. D, D′: dstn. E, E′: coro1a. F, F′: ptpn6. G, G′: timp–1. H, H′: fmnl1. I, I′: ctss. J, J′: adam28.

Gene Clone Species Stages Anatomy
mmp7.L image:5572538 laevis NF stage 23 anterior ventral blood island , myeloid cell

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  Figure 3. Knockdown of primitive myeloid lineage spib.a transcription factor results in loss of myeloid gene candidate expression in the anterior ventral blood island (aVBI) of stage 23 embryos. A–J: Normal expression of genes in the aVBI of uninjected control embryos. A′–J′: Reduced aVBI expression of genes in the embryos injected dorsally at 4-cell stage with 40 ng e1i1 spib.a morpholino. A+A′, spib.a. B+B′, mpo. C+C′, mmp7. D+D′, adam28. E+E′, coro1a. F+F′, ctss. G+G′, dstn. H+H′, fmnl1. I+I′, timp-1. J+J′, ptpn6.