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lmo2xenopus   

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Experiment details for lmo2

Liu F et al. (2008) Assay

Fli1 acts at the top of the transcriptional network driving blood and endothelial development.

Gene Clone Species Stages Anatomy
lmo2.S laevis NF stage 17

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  Figure S4. Control tissues and genes abutting the anterior hemangioblast are unaffected in Fli1 morphants. 40 ng Fli1 MO was injected into the DMZ at the 4/8 cell stage and embryos were grown to stage 17. Rohon Beard neuron expression of Runx1 (A,B) and somite expression of Lmo2 (C,D) was unchanged in Fli1 morphants. MyoD, Nkx2.5, Blimp1 and Bmp4 expression abuts the anterior hemangioblast but in no case does expression of these genes increase in the hemangioblast territory (asterisks) in Fli1 morphants (E-L), indicating that in the morphants re-specification is not the reason for lost hemangioblast gene expression.

Gene Clone Species Stages Anatomy
lmo2.S laevis NF stage 24 midbrain , head region , notochord , presomitic mesoderm , ventral blood island , [+]

  lmo2 (LIM domain only 2 (rhombotin-like 1)) gene expression in Xenopus laevis embryo, NF stage 24, assayed by in situ hybridization, lateral view, anterior left, dorsal up.