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krt12.4xenopus   

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Experiment details for krt12.4



Xenopus BTBD6 and its Drosophila homologue lute are required for neuronal development.

Gene Clone Species Stages Anatomy
krt12.4.L laevis NF stage 17 ectoderm , epidermis , non-neural ectoderm

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  Figure 3. Knockdown of XBTBD6 affects the expression of late but not early neuronal markers and causes axonal outgrowth defects. A-F: Dorsal views of embryos injected with XBTBD6 MO1 and hybridized with the indicated probes. Reduced staining on the injected side in F is indicated (arrowhead). G-I: Control and injected sides of XBTBD6 MO1 (G,H) or XBTBD6 MO1mis (I) injected embryos in the trunk (G) or head region (H,I) immunostained with a HNK-1 antibody. Arrowheads in G and H points to reduced or disorganized axon tracks on the injected sides. Nuc-LacZ was used as a lineage tracer.