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FIG. 6. Pools of mRNAs induce changes in a-globin and Pax-8 expression. Individual clones were not isolated (see text). All embryos are
shown with anterior to the left. (A) Uninjected control stained for expression of a-globin (ventral blood islands). (B, C, D) Embryos injected
with pools 18A1 (B), 28B1 (C), and 28B2 (D) showed disruption of a-globin and gross morphology. (E) Uninjected control stained for
expression of Pax-8 (otic vesicle and kidney). (F, G, H) Pools 120A2 (F), 121A2 (G), and 5A2 (H) perturbed the expression of Pax-8. Embryos
injected with 5A2 also showed a distinct head kink. |