|
Gene |
Clone |
Species |
Stages |
Anatomy |
hand2.L
|
|
laevis
|
NF stage 15
to
NF stage 20
|
anterior neural fold
,
cardiac progenitor cell
|
hand2.L
|
|
laevis
|
NF stage 20
|
mesoderm
,
ventro-lateral
,
cranial neural crest
|
hand2.L
|
|
laevis
|
NF stage 24
|
heart
,
lateral plate mesoderm
,
heart primordium
,
cranial neural crest
,
cardiac progenitor cell
|
hand2.L
|
|
laevis
|
NF stage 29 and 30
|
heart
,
branchial arch
,
heart primordium
,
endocardial tube
|
Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
foxc1
|
|
laevis
|
NF stage 24
to
NF stage 29 and 30
|
mesoderm
,
heart
,
branchial arch
,
ventral
,
heart primordium
,
[+]
|
foxc1
|
|
laevis
|
NF stage 15
to
NF stage 16
|
neural plate
,
cranial neural crest
,
anterior
,
cardiac progenitor cell
|
foxc1
|
|
laevis
|
NF stage 20
|
mesoderm
,
cardiac progenitor cell
|
hand1
|
|
laevis
|
NF stage 15
|
mesoderm
,
ventral
,
anterior
,
cardiac progenitor cell
|
hand1
|
|
laevis
|
NF stage 20
|
lateral plate mesoderm
,
cardiac progenitor cell
|
hand1
|
|
laevis
|
NF stage 24
to
NF stage 29 and 30
|
mesoderm
,
heart
,
ventro-lateral
,
heart primordium
|
actc1
|
|
laevis
|
NF stage 15
to
NF stage 29 and 30
|
cardiac progenitor cell
|
foxc2
|
|
laevis
|
NF stage 15
to
NF stage 16
|
mesoderm
,
neural plate
,
dorso-lateral
|
foxc2
|
|
laevis
|
NF stage 20
|
mesoderm
,
cardiac progenitor cell
|
foxc2
|
|
laevis
|
NF stage 24
to
NF stage 29 and 30
|
neural crest
,
heart
,
branchial arch
,
heart primordium
,
cranial neural crest
,
[+]
|
mef2d
|
|
laevis
|
NF stage 15
|
neural crest
,
cranial neural crest
|
mef2d
|
|
laevis
|
NF stage 20
|
neural plate
,
lateral plate mesoderm
,
cardiac progenitor cell
|
mef2d
|
|
laevis
|
NF stage 24
|
mesoderm
,
paraxial mesoderm
,
heart primordium
,
cranial neural crest
,
cardiac progenitor cell
|
mef2d
|
|
laevis
|
NF stage 29 and 30
|
mandibular crest
,
hyoid crest
,
branchial crest
,
head region
,
head mesoderm
,
[+]
|
mef2c
|
|
laevis
|
NF stage 15
to
NF stage 20
|
neural crest
,
cranial neural crest
|
mef2c
|
|
laevis
|
NF stage 24
to
NF stage 29 and 30
|
head region
,
mesoderm
,
heart
,
cardiac mesoderm
,
heart primordium
|
tnni3
|
|
laevis
|
NF stage 15
to
NF stage 29 and 30
|
cardiac progenitor cell
|
ror2
|
|
laevis
|
NF stage 15
|
neuroectoderm
,
neural plate
,
anterior
|
ror2
|
|
laevis
|
NF stage 20
|
neuroectoderm
,
lateral plate mesoderm
,
cranial neural crest
|
ror2
|
|
laevis
|
NF stage 24
|
neuroectoderm
,
heart primordium
,
cranial neural crest
,
cardiac progenitor cell
|
ror2
|
|
laevis
|
NF stage 29 and 30
|
mandibular crest
,
hyoid crest
,
branchial crest
,
head region
,
heart primordium
,
[+]
|
alcam
|
|
laevis
|
NF stage 15
|
neuroectoderm
,
neural plate
,
anterior
|
alcam
|
|
laevis
|
NF stage 20
|
neuroectoderm
,
trigeminal placode
,
eye primordium
,
anterior neural tube
,
neural tube
|
alcam
|
|
laevis
|
NF stage 24
|
trigeminal placode
,
anterior neural tube
,
cardiac progenitor cell
|
alcam
|
|
laevis
|
NF stage 29 and 30
|
midbrain-hindbrain boundary
,
neuroectoderm
,
heart
,
heart primordium
,
neural tube
|
wnt11
|
|
laevis
|
NF stage 15
to
NF stage 29 and 30
|
cardiac progenitor cell
|
cdh2
|
|
laevis
|
NF stage 15
to
NF stage 29 and 30
|
cardiac progenitor cell
|
foxh1
|
|
laevis
|
NF stage 15
to
NF stage 16
|
neural plate
|
foxh1
|
|
laevis
|
NF stage 20
to
NF stage 29 and 30
|
heart
,
heart primordium
,
cardiac progenitor cell
|
|
|
Fig. 3. (A) Cardiac expression pattern of FoxH1, FoxC1, FoxC2, dHand, eHand, Mef2c and Mef2d during Xenopus laevis. (B) Expression of the cardiac differentiation marker genes DM-GRASP, MHCα, cActin, TnIc, N-Cadherin as well as Wnt11-R and Ror2 during cardiac development. For stages 15/16 and 20 anterior views are shown, stages 24 and 29 are from the ventral side, anterior is to the top. Dotted lines indicate the cement gland. |
|
Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
foxc1
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
heart
,
myocardium
,
pronephric kidney
,
posterior
|
hand1
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
heart
,
myocardium
,
posterior
,
cardiac ventricle
|
actc1
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
somite
,
heart
,
myocardium
,
paraxial mesoderm
,
trunk somite
,
[+]
|
foxc2
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
somite
,
heart
,
myocardium
,
paraxial mesoderm
,
trunk somite
,
[+]
|
mef2d
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
heart
,
myocardium
,
cardiac mesoderm
,
posterior
|
mef2c
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
head region
,
heart
,
myocardium
,
paraxial mesoderm
|
tnni3
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
heart
,
myocardium
,
endocardial tube
|
ror2
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
heart
,
myocardium
,
pharyngeal arch
,
mandibular arch
,
hyoid arch
,
[+]
|
alcam
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
brain
,
midbrain-hindbrain boundary
,
cranial ganglion
,
pronephric duct
,
heart
,
[+]
|
wnt11
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
cement gland primordium
,
somite
,
heart
,
branchial arch
,
dorsal
,
[+]
|
cdh2
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
heart
,
myocardium
|
myh6
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
heart
,
myocardium
|
foxh1
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
somite
,
heart
,
myocardium
,
paraxial mesoderm
,
trunk somite
,
[+]
|
|
|
Fig. 7. (A) Expression of FoxH1, FoxC1, FoxC2, dHand, eHand, Mef2c and Mef2d at stage 30/31 in Xenopus laevis embryos. (B) Spatial expression pattern of DM-GRASP, Ror2, Wnt11-R, MHCα, cActin, cTnIc and N-Cadherin at stage 30/31. Embryos in the upper raw are shown from the lateral side. The dashed lines indicate the levels A (anterior part of the heart), B (closing linear heart tube) and C (IFT forming tissue) of transverse sections. |