|
Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
eomes
|
|
laevis
|
NF stage 29 and 30
|
brain
,
forebrain
,
telencephalon
|
arx
|
|
laevis
|
NF stage 16
|
diencephalon
,
neural plate
|
arx
|
|
laevis
|
NF stage 22
to
NF stage 31
|
brain
,
telencephalon
,
diencephalon
,
spinal cord
,
neuroectoderm
,
[+]
|
nkx2-1
|
|
laevis
|
NF stage 31
|
brain
,
forebrain
,
telencephalon
,
neuroectoderm
|
rax
|
|
laevis
|
NF stage 16
|
neural plate
,
anterior
|
rax
|
|
laevis
|
NF stage 24
|
neuroectoderm
,
neural plate
,
anterior
|
dlx5
|
|
laevis
|
NF stage 26
|
olfactory placode
,
brain
,
forebrain
,
neuroectoderm
,
cement gland primordium
,
[+]
|
en2
|
|
laevis
|
NF stage 22
|
midbrain-hindbrain boundary
,
neuroectoderm
,
neural plate
|
emx1
|
|
laevis
|
NF stage 29 and 30
|
forebrain
|
otx1
|
|
laevis
|
NF stage 22
|
forebrain
,
diencephalon
,
neuroectoderm
,
neural plate
,
anterior
|
|
|
Figure 1. XArx is expressed in a dynamic pattern in the developing diencephalon and telencephalon. A-L: Double whole-mount in situ hybridization (WISH) using antisense riboprobes specific for xArx (blue color) and other forebrain markers (in red): Rx2A (A,B), otx1 (C), en-2 (D), FoxG1 (E-H), dlx5 (I), emx1 [note typological error- 'mex1' sic] (J), Nkx2.1 (K), and eomesodermin (L). Regions of overlap appear purple. At neural plate and neural tube stages, xArx expression is caudal/posterior to telencephalic markers such as Rx2A and FoxG1. XArx expression is rostral to otx1 and en-2. E-H: xArx is expressed caudal to FoxG1 at neural plate and neural tube stages. During tailbud stages, xArx expression spreads rostrally to overlap a portion of the FoxG1 expression domain (arrow in H). XArx expression also overlaps expression of dlx5, mex1, Nkx2.1, and eomesodermin. Anterior views are shown in A-I. Lateral views are shown in J-L. |